Báo cáo khoa học: BRCA1 accumulates in the nucleus in respon

Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf

... Authors Journal compilation ª 2007 FEBS BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL- induced apoptosis in breast cancer cells Latricia D. Fitzgerald 1, *, Charvann ... 22-fold enhancement in apoptosis relative to cells expressing BRCA1 in the absence of TRAIL and a three-fold enhancement of apopto...

Ngày tải lên : 30/03/2014, 03:20

10
392
0

Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx

... pregnenolone synthesis in recombinant yeast. In conclusion, the SCC reaction appears to be regulated similarlyinyeastandinadrenalcells;inthelatter,Adxpand not Adrp limits the activity of CYP11A1 and hence ... the CYP11A1 antigen appears to be excluded from mitochondria in vivo, and most of the antigen is detected in the plasma membrane, with a minor fraction localizi...

Ngày tải lên : 08/03/2014, 08:20

13
441
0

Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf

... vectors containing the mutations of the miR-23a binding site (Fig. 4A). It was shown that miR-23a ASO or pcDNA3 ⁄ pri-23a did not affect the intensity of EGFP ﬂuorescence in the vector bearing the ... ﬂuorescent reporter, and found an increase in EGFP intensity after blocking miR-23a and a decrease in EGFP intensity after overexpressing miR-23a. Furthermore, another three...

Ngày tải lên : 18/02/2014, 04:20

9
541
0

Tài liệu Báo cáo khoa học: Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells docx

... sixfold increase in hepatocyte nonheme Fe. This strongly suggests a role for the liver in binding, storing and detoxifying excess body Fe in the form of plasma NTBI. While these hepatoma cells took ... a big increase in the proportion of Fe in the cytosol suggest that all the chelators including DFO and DFP, act in part intracellularly, mobilizing Fe from ferritin...

Ngày tải lên : 20/02/2014, 11:20

10
545
0

Báo cáo khoa học: Structural ﬂexibility of the methanogenic-type seryl-tRNA synthetase active site and its implication for speciﬁc substrate recognition pptx

... of the conserved arginine residues in the motif 2 loop show a concerted movement following substrate binding in the active site. In the apo-enzyme, the motif 2 Arg336 occupies the adenine-binding ... which is in close proximity to the negatively charged carboxylate group of the amino acid substrate [21]. The binding of ATP and the amino acid substrate in t...

Ngày tải lên : 16/03/2014, 06:20

14
357
0

Báo cáo khoa học: Structural study of the catalytic domain of PKCf using infrared spectroscopy and two-dimensional infrared correlation spectroscopy pot

... functional domains and motifs, including a PB1 domain in the N-terminus, a pseudosubstrate (PS) sequence, a C1 domain of a single Cys-rich zinc-ﬁnger motif, and a kinase domain in the C-terminus. The catalytic ... increase). It seems, then, that this substrate was able to modulate the sec- ondary structure signiﬁcantly. To gain further insight into the structure and fo...

Ngày tải lên : 16/03/2014, 13:20

14
383
0

Báo cáo khoa học: Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways doc

... interaction. Dematin and Ras-GRF2 associate in mouse brain lysate and in transfected epithelial cells To test whether Ras-GRF2 and dematin associate in vivo, we examined their association in mouse brain lysate ... domain of Ras-GRF2 stimulates the activation of the MAP kinase ERK1 and Ras upon in ux of intracellular calcium in A293 cells [22,26]. First, we wanted...

Ngày tải lên : 17/03/2014, 11:20

12
405
0

Báo cáo khoa học: Identiﬁcation of the N-termini of NADPH : protochlorophyllide oxidoreductase A and B from barley etioplasts (Hordeum vulgare L.) ppt

... found N-terminal to the arginine. Alanine or threonine is found C-terminal to the processing site. Similar amino acids are present around the processing site in POR of pea. Glutamine has been found to ... modiﬁes the N-terminal amino groups of internal peptides, the hydrophobicity of the corresponding peptides is increased, leading to a delay in the retention time du...

Ngày tải lên : 30/03/2014, 02:20

8
362
0

Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in ﬁsh pdf

... chelate one zinc ion each, and binds to the minor groove of the DNA [6]. Dmrts were originally described to play important roles during sex determination in ﬂies and worms by regulating several aspects ... FEBS rather than being continuously mature individuals. In general, for males, abundant dmrt1 expression during preparatory and prespawning and spermatogenesis periods w...

Ngày tải lên : 14/02/2014, 19:20

10
860
0

Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt

... from the R1 subunit back to the tyro- sine Y122 of the R2 subunit; and (d) dedocking of the product deoxyribonucleotide and reduction of the disulﬁde cysteine by NADPH. In in vitro stud- ies, the ... [35] may not be considered in the light of the results obtained in the present study. Rather, the involvement of manganese in the in vivo assembly of the m...

Ngày tải lên : 15/02/2014, 01:20

14
872
0