... that Pfkfb3 gene
expression is increased in streptozotocin-induced diabetic mouse liver. The
Pfkfb3 ⁄ -3566 promoter construct linked to the luciferase reporter gene was
delivered to the liver ... This promoter was
upregulated in streptozotocin-induced diabetic mouse liver compared with
transfected healthy cohorts. In addition, increases were observed in Pfkfb3...
... as insulin receptor sub-
strates and adiponectin [8,9], resulting in obesity-related
insulin resistance [11–13]. In an in vitro model of ER
stress induced by proteasome inhibition, the stress
induced ... adaptor protein that interacts with adiponectin
receptors, insulin and adiponectin signaling are now
considered to be linked in the peripheral organs of
insulin action, such as the l...
... finer grained semantics
with respect to other languages (for instance
en
in
Spanish is vague between the Contact and Container
senses of the Location, whereas in English it is finer
grained, ... ended up going to the
(financial-institution OR river-shore), whatever this
object might be!, instead of a) going to the financial-
institution OR b) going to the river-shore.
In thi...
... utility
of modelling in the study of T. brucei glycolysis has even led
to the coining of a new strategy for the investigation of
metabolism: computer experimentation [11]. This is inten-
ded to ... a
secondary role for hexokinase and the remainder of main-
chain glycolysis having only minimal relevance. This pattern
has previously been observed in a study of glycolytic flux
control in...
... that is
dominant in the deceptive corpus, and thus likely
to be a characteristic of the texts in this corpus.
Finally, a score significantly lower than 1 indicates
a class that is dominant in the ... truth/deception,
and it is not bound to a particular topic.
5 Identifying Dominant Word Classes in
Deceptive Text
In order to gain a better understanding of the char-
acteristics o...
... also
determine IS using domain knowledge.
3 Information Structure
Information structure (IS) is an inherent aspect
of meaning; it is important for establishing co-
herence and getting the intended ... Background/Focus partitioning dis-
tinguishes between alternatives in context.
Our approach to assigning IS is similar to Pre-
vost's in assigning IS according to the precedin...
... FEBS
Interruption of triacylglycerol synthesis in the
endoplasmic reticulum is the initiating event for saturated
fatty acid-induced lipotoxicity in liver cells
Michalis D. Mantzaris
1
, Epameinondas ... TAG synthesis
was initially hindered following stearate administration
and was completely interrupted at longer incubation
periods. Interestingly, the interruption of TAG synthe-
sis...
... His, His41, in NirF by
Ala abolished binding of the heme to the protein.
Known distal heme-binding residues, such as Met, Lys
or Cys [18,19], were substituted for His41 in NirF. No
changes in ... with the C-terminal d
1
heme-containing domain of
cytochrome cd
1
. Strikingly, the axial ligand of iron in
d
1
heme in P. pantotrophus cd
1
(His200) is conserved in
NirF (His41); this...
... specificity for PDI is nonexistent. Bacitracin
is also used medicinally to prevent infections in small
cuts and burns and to treat gastrointestinal infections.
In addition, it is used as an animal ... pancreatic trypsin inhibitor (BPTI)
refolding assay. BPTI is a widely studied protein con-
taining three disulfides in the native form. In a gluta-
thione-based refolding buffer, B...
... degrades
mRNAs harboring premature termination codons. In
humans, nonsense-mediated mRNA is linked to
splicing, but in Drosophila and also in Caenorhabditis
elegans, it occurs independently of introns. A ... as
was discussed by Javier F. Caceres (Edinburgh, UK).
The trans-acting factors involved include both serine-
arginine (SR) and heterogeneous nuclear ribonucleo-
protein (hnRNP) A...