Báo cáo khoa học: Wisely chosen paths – regulation of rRNA synthesis Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden potx

... Regulation of rRNA synthesis FEBS Journal 277 (2010) 462 6–4 639 ª 2010 The Author Journal compilation ª 2010 FEBS 4639 THE FEBS ⁄ EMBO WOMEN IN SCIENCE LECTURE Wisely chosen paths – regulation of rRNA ... phosphorylation of the C-terminal activation domain of UBF [28], under-scoring the importance of UBF phosphorylation in the control of rRNA synthesis. In addition to transcriptioninitiation, phosphorylation ... transcription regulation. Cells regulate rRNA synthesis by modulating the rate of transcription initiation,thereby controlling the number of nascent pre -rRNA molecules (green lines) that are generated...

Báo cáo khoa học: How a lipid mediates tumour suppression Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden pdf

... functions of PtdIns3P [29]. Additional PtdIns3P-binding proteinsthat do not contain FYVE or PX domains include the Proppin ⁄ WIPI proteins, which bind PtdIns3P [and tosome extent the related PtdIns(3,5)P2] ... deubiquitinat-ed by deubiquitinating enzymes recruited by ESCRT-III[61], and ESCRT-III serves to sever the neck of the forming invagination, thereby securing the inclusion of cargo proteins within ... Stenmark4848 FEBS Journal 277 (2010) 483 7–4 848 ª 2010 The Author Journal compilation ª 2010 FEBS THE SIR HANS KREBS LECTUREHow a lipid mediates tumour suppression Delivered on 29 June 2010 at the 35th FEBS...

Báo cáo khoa học: Pharmacology of vascular endothelium Delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw pptx

... hydrophilicpravastatin) at a concentration of 30 lm mobilize freecytoplasmic calcium [Ca2+]ito 3 0–5 0% of thatinduced by Bk at a concentration of 10 nm. In the case of simvastatin and lovastatin, this ... their stimulatoryeffect on the endothelial generation of PGI2and NO•.There are other propositions concerning the mechan-ism of endothelial actions of statins, e.g. the induction of heme oxygenase ... for the further ampliﬁcation of ONOO – generation by endothelial cells. This newlymade ONOO – selectively nitrates Tyr 430 in the enzy-mic protein of endothelial PGIS. When PGI2is elimin-ated...

Báo cáo khoa học: The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw potx

... preventing the formation of the competing Orp1 Cys36-Cys82 disulﬁde bond. Onceactivated, the Yap1 NES that lies within the c-CRD ismasked leading to its retention in the nucleus and the up -regulation ... unpublished data). Nuclearlocalization of the fusion protein correlates not only withactivation of FRM2 transcription, but also with growth in increasing concentrations of cadmium but not of H2O2. ... others, suggesting a role in the response todrug stress. Indeed, several target genes encoding a set of proteins involved in the stabilization and folding of pro-teins in an oxidative environment...

Báo cáo khoa học: A decade of Cdc14 – a personal perspective Delivered on 9 July 2007 at the 32nd FEBS Congress in Vienna, Austria pdf

... thisquestion. In particular, I was interested in determining the role of CDKs in the regulation of mitotic Clb cyclindegradation, by examining the consequences of CDKinactivation on mitotic Clb cyclin ... is the case. Cdc14 is the phosphatase thatdephosphorylates Cdh1. Its inactivation has the mostdramatic effect on Clb cyclin degradation. CDC15 is acomponent of one of the two pathways that ... which inhibits Cdc14–Cﬁ1 ⁄ Net1 dissociation. Movement of the MEN-bearing SPB into the bud, where Lte1 islocated, downregulation of Bub2–Bfa1 activity by Cdc5, inactivation of Kin4 and other...

Báo cáo khoa học: Diversity of human U2AF splicing factors Based on the EMBO Lecture delivered on 7 July 2005 at the 30th FEBS Congress in Budapest pptx

... Schematic representation of protein–protein and protein–RNAinteractions mediated by the U2AF heterodimer during the earlysteps of spliceosome assembly. Binding of the U2AF heterodimer to the ... for splicing of at least certain pre-mRNAs in vitro [19]. The N-terminal amino acids 8 5–1 12 of U2AF65interact with U2AF35, and this associationfurther strengthens the binding to the Py-tract ... diversity of U2AF pro-teins and we discuss the resulting implications forsplicing regulation. Structural features of U2AF andU2AF-related proteins The U2AF65protein contains three RNA-recognitionmotifs...

Báo cáo khoa học: Mitochondrial calcium signalling in cell death Delivered on 1 July 2004 at the 29th FEBS Congress in Warsaw pptx

... Ca2+-dependent inhibition of cel-lular responses. The other physiological regulation of mitochondriathat has been studied in relation to Ca2+signalling is the state of fusion and ﬁssion. The study of ... up in recent yearsindicating that metabolic regulation is only one of the roles of the mitochondrial Ca2+signal. It now appearsevident that massive Ca2+loading (as in the case of glutamate ... role in modulating physiological and pathological events, such as the regulation of aerobic metabolism and the induction of cell death, and new insight into the regulatory mechanisms operating in...

Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt

... activation of checkpoint kinases belonging to the family of phospha-tidylinositol-3-OH-kinase-like protein kinases. The currently best studied phosphatidylinositol-3-OH-kinase-like protein kinase ... replication in the Sphase. Here, single-stranded DNA becomes opsonizedby the replication protein A, which recruits ATR via the ATR-interacting protein to the DNA lesions andorchestrates DNA-topoisomerase ... Furthermore, ATM and ATR mediate HIPK2 activation by facili-tating its stabilization through phosphorylation of the HIPK2 ubiquitin ligase, Siah1, which facilitates disruption of the HIPK2–Siah1 complex.Once...

Báo cáo khoa học: Gonadotropin-releasing hormone: regulation of the GnRH gene pot

... Ref.28 –1 571 –1 780/ –1 772Oct–1 (–1 569/ –1 562) Ref.49GATA (–1 748/ –1 743) Ref.10 –1 746/ –1 738 –1 736/ –1 728GATA (–1 715/ –1 710) Ref.10 –1 697/ –1 689C/EBP (–1 684/ –1 676)Oct–1 (–1 10/ –8 8) Ref.12 ... withoutOct-1. Within those Pbx1 ⁄ Prep1-binding motifs, onlymutation in the )1749 bp binding site can eliminate the activation, indicating that the transactivation isspeciﬁcally dependent on this motif.Otx2 In ... be integrated at the hypotha-lamic level [110]. The development of neuron-speciﬁcinsulin receptor knockout (NIRKO) mice revealed the involvement of insulin signaling in the regulation of the...

Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt

... pointing a rrows indicate the relative positions of the 5¢- ends of the cDNA clone s identiﬁed by 5¢-RLM-RACE compared to the exon/intron organization of the CB1 gene. The major transcription initiation ... in HD mouse brain. T his supports the hypothesis that the rate of transcription of CB1 in the striatum of symptomatic R6/2mice is similar to the rate of transcription i n regions of the brain ... expression of the gene encoding mutant huntingtin(HD). Although it is known that the coding region of CB1 iscontained within a single exon in mice, rats and humans, the 5¢-untranslated r egion o...

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