... domain at their C-terminus, and a lessconserved proline-rich and glutamine-rich transactiva-tion domain at their N-terminus [8–10]. Most isoformsalso have a PY-motif (XPPXY) in the N-terminal ... specificallyexpressed in the central nervous system, retina, and developing heart [6]. AP-2e expression has beendetected in the developing olfactory bulb, neural tis-sue, especially the midbrain and hindbrain ... AP-2d, and AP-2e. The proline-rich and glutamine-rich N-terminus, which is important fortransactivation, is shown in yellow, and contains the PY-motif (green). The helix–span–helix domain at the...