... proteins are
present in all three domains of life (IF1 in bacteria,
aIF1A in archeaons, and eIF1A in eukaryotes) [4,5].
IF1 is the smallest of the three initiation factors in
E. coli. During initiation ... of translation initiation by IF1
FEBS Journal 277 (2010) 2428–2439 ª 2010 The Authors Journal compilation ª 2010 FEBS 2439
Translation initiation regi...
... evaluating incremental system changes
and optimizing systems through minimum er-
ror rate training (Och, 2003). Conference pa-
pers routinely claim improvements in translation
quality by reporting ... and
a hypothesis translation from the 2005 NIST MT
Evaluation
in speech recognition, because translations have a
degree of variation in terms of word choice and in
terms...
... (2001)
Binding of gelsolin domain 2 to actin. An actin interface
distinct from that of gelsolin domain 1 and from
ADF ⁄ cofilin. Eur J Biochem 268, 6165–6175.
Calpain 1–titin interactions in myofibrils ... have directed our
investigations towards titin–calpain 1 interactions.
The binding of calpain 1 to the N-terminal region of
titin was investigated in vitro by using two dist...
... roles in the induction of
mitochondria-mediated apoptosis and the inhibition of invasion, along with
the downregulation of matrix metalloproteinase expression. In addition, by
using the calcium indicator ... additional
occludin variant deleted in exon 9 (Occ
DE9
). On the
basis of a comparative analysis of the involvement of
wild-type occludin (Occ
WT
) and variant occ...
... of Illinois at Urbana-Champaign, Urbana, IL USA
2 Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore
3 Division of Environmental Science and Engineering, ... 2-isopropylalinine (2IPA), aniline and 2,4-dimethylalanine (24DMA) by E. coli JM109 expressing the wild-type
AtdA enzyme and the V205A and I248L mutants.
AtdA3
2IPA Anil...
... application of shuffle
constraints. By delaying the application of shuffle
constraints until the linear position of each element
is known, and by using an efficient encoding of the
portions of the input ... produced by the shuffle
constraint will be those that correspond to the or-
der of words in the actual input sequence.
Since the portion of the input string...
... the regions of the protein
involved in interaction with Cdk2 and
cyclin A: 1, domain 1 interacting with
cyclin A; 2, a linker helix involved in binding
both cyclin A and Cdk2; 3, domain 2 inter-
acting ... example of GSK3b,
in which different regions of intrinsic disorder are inde-
pendently involved in different regulatory pathways,
suggests that identifying and catalogui...
... determined from data obtained by
changing the concentration of the linking intermediate
and measuring the corresponding rates of the modules
(i.e. from module rates versus S data). Changes in the
intermediate ... changed, for the system in Fig. 3 (solid lines) and the system
modified by eliminating G-I allosteric interactions (dashed lines).
The main effects on the control patt...
... cytochrome b
and is involved in interactions with the peripheral domain of
the iron–sulphur protein. The stigmatellin head-group binds
in this distal lobe of the Q
o
site and is positioned in a pocket
formed ... competence of the different constructs in
the presence of stigmatellin, which binds in the distal lobe
of the Q
o
site, and myxothiazol, azoxystrobin and p...
... Lopaschuk, G.D. (1997) Insulin inhibition of
5¢-adenosine monophosphate-activated protein kinase in the heart
results in activation of acetyl coenzyme A carboxylase and inhi-
bition of fatty acid oxidation. ... phosphorylation and inhibition
of ACC [18,20–24]. This activation of AMPK and inhibi-
tion of ACC results in a dramatic drop in malonyl-CoA
levels during and...