Báo cáo khoa học: Ets-1/ Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells pdf

Báo cáo khoa học: Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex pptx

... contains two arginine ⁄ glycine-rich(RGG) motifs that are characteristic of RNA-bindingproteins, and an alanine-rich carboxy-terminal sequencethat could be involved in protein–protein interactions.Interestingly, ... homologs are poly (A) polymerases. Proc Natl Acad Sci USA 101, 4407–4412.18 Nakanishi T, Kubota H, Ishibashi N, Kumagai S,Watanabe H, Yamashita M, Kashiwabara S, Miyado K& Baba T (2006) ... EcoRIsite of the pADGal4 vector.MS2 fusion protein. cDNA encoding XRbm9 was clonedas a PCR product using the primers 5¢-TGCTAGCATGGCAGATGCTGTAATG-3¢ and 5¢-CCTCGAGTCAGTACGGAGCAAATCG-3¢ containing...

Tài liệu Báo cáo khoa học: KIPase activity is a novel caspase-like activity associated with cell proliferation doc

... Ac-YVAD-AMC is a substrate for caspase 1;Ac-IETD-AMC is a substrate for caspase 8 and 10;Ac-LEHD-AMC is a substrate for caspases 2, 4, 5 and 9.Ac-DVPD-AMC, Ac-DPSD-AMC and Ac-ESQD-AMCare tetra peptide ... horizontal lineindicates an induction value of 1.Fig. 6. Comparison of the ability of recombinant human caspases tocleave DPSD-AMC. The human recombinant caspases were assayedfor their ability ... Interestingly, a distantrelative of the caspases, termed paracaspase, was identiﬁed in Homo sapiens using a PSI-BLASTsearch [39]. Paracaspasecould be a candidate gene for KIPase although no caspaseactivity...

Tài liệu Báo cáo khoa học: Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum ppt

... TAT ATG T Weak 3 aa2 ⁄ 4 55067 TCA ATG C Weak 58 aa3 33 39% 609296093360939GTA ATG CTGC ATG TTCC ATG GGAdequateWeakAdequate13 aa33 aa31 aa3¢ 76 49% –4¢ 56 61% 61041 GGA ATG T Adequate ... thecarboxy tail of Hu-K4. The apparent molecular mass of 65 kDa is higher than the calculated molecular mass of 55 kDa for Hu-K4 hinting at a post-translationalmodiﬁcation, e.g. glycosylation, of ... membrane or with themembranes of intracellular organelles although theylack a transmembrane domain. They are attached tothe cytoplasmic face of the membranes via palmitoylanchors [15] as is...

Báo cáo khoa học: Syndecan-4 is a signaling molecule for stromal cell-derived factor-1 (SDF-1)/ CXCL12 pptx

... (2002) Interaction of the CC-chemokine RANTES with glycosaminogly-cans activates a p44 ⁄ p42 mitogen-activated protein kin-ase-dependent signaling pathway and enhances human Syndecan-4 is an auxiliary ... (Fig. 5A, lane 1).These data strongly indicate that SDF-1 induces a rapidand signiﬁcant increase in the tyrosine phosphorylation of SD-4 on HeLa cells and that a physical association of tyrosine ... 12-myristate-13-acetate (PMA) induced a rapid activation of p44 ⁄ 42MAPK and JNK ⁄ SAP kinase signaling in HeLa cells by increasing phosphorylations of the respective pro-teins (Fig. 6). This effect was...

Báo cáo khoa học: Cytochrome b6f is a dimeric protochlorophyll a binding complex in etioplasts doc

... 6803[7], indicating a structural or a functional role for bothpigments. A structural role was indicated in a Chl-less mutantthat was reported to lack accumulation of theCyt b6f complex in Clamydomonas ... show in etio-plasts that a Cyt b6f complex can be isolated with a molecular mass and subunit composition indistinguish-able from dimeric Cyt b6f isolated from chloroplasts.Analysis of the ... ﬁndings argue for a replacement of Chl against Pchl in etioplasts. Replace-ment of a cofactor in the dimeric Cyt b6f complex hasbeen reported also in Synecochystis mutants deﬁcient in echinenone...

Báo cáo khoa học: Bacterial IscU is a well folded and functional single domain protein pdf

... Bacterial IscU is a well folded and functional single domain proteinSalvatore Adinolﬁ1, Francesca Rizzo1, Laura Masino1, Margie Nair1, Stephen R. Martin1, Annalisa Pastore1and ... solvent is observed.Binding of a paramagnetic species leads instead to majorFig. 4. Probing the aggregation state of IscU. (Top) Calibration curvefor apparent molecular mass determination of E. ... studies hint at a mechanism forprokaryotes in which IscS and IscU play a central role [3,4].This mechanism however, is also preserved in eukaryotic cells. IscS is analogous to NifS as it provides...

Tài liệu Báo cáo khoa học: ˚ The 1.8 A crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species docx

... pre-proenzyme including an N-terminal chaperone likedomain, the catalytic domain and two similar C-ter-minal domains with unknown structure and function.The N-terminal pro domain is autocatalytically ... atoms of the side chains of Asp11, Asp14 and Asp21, the amideoxygen atom of Gln15 and the carbonyl oxygen atoms of Asp11 and Asn23 (Fig. 3) in an arrangement similarto what is observed in VPRK. ... direction of the main chain of the tripeptide is antiparallel to thenaturally occurring inhibitors. It was ﬁrst speculatedwhether the C-terminal domain in an uncleaved statecould fold back into...

Tài liệu Báo cáo khóa học: The PAS fold A redeﬁnition of the PAS domain based upon structural prediction ppt

... contain a PAS domain.Therefore, in the case of A. thaliana,thePASandPACmotifs are inseparable, indicating that the annotation of these proteins as containing only PAS or PAC motifs is questionable. ... PASproteins, is depicted in Fig. 3. We conclude from thisalignment that all PAS-annotated A. thaliana proteins alsocontain a PAC motif, and conversely that all PAC-annotated A. thaliana proteins ... Ponting and Aravind ([3])observed that conserved motifs representative of PASdomains were ubiquitous in archaea, bacteria and eucarya,and that many PAS containing proteins were involved in...

Báo cáo khoa học: "Creative Language Retrieval: A Robust Hybrid of Information Retrieval and Linguistic Creativity" pot

... statisticalbreadth and convenience of automatic expansion.Fortunately, statistical corpus analysis is an ob-vious area of overlap for IR and FLP. Distribu-tional analyses of large corpora ... embedded within a larger sea of noise.Creative IR can be used to explore this idea space.Each creative query is a jumping off point in a space of lexicalized ideas that is implied by a largecorpus, ... viewed asstars). Mason (2004) shows how statistical analysiscan automatically detect and extract conventionalmetaphors from corpora, though creative meta-phors still remain a tantalizing challenge....

Báo cáo khoa học: "GAMR VIEWED AS A FUNCTIONING PART OF A COGNITIVES SERM A YTM" pot

... support as separately definable knowledge within studies of aphasia. There is a vast literature concerning what aspects of language are indepen- dently affected in aphasia that has been used as a ... to access meanings.) Using spreading activation, the syntactic category aspect of each meaning in turn activates the category's meaning in the grammar space representation. Part of ... simultaneously. An example related to the grammatical representation is that the syntactic category aspect of each meaning of a phonetic word is also a part of the grammatical representation...

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