... Boc-Glu(Obzl)-Ala-Arg-MCA, which are substrates for trypsin and factor XIa,respectively, and weakly cleaved Boc-Val-Pro-Arg-MCA, Pro-Phe-Arg-MCA, l-Pyroglutamyl (Glp)-Arg-MCA, and Boc-Phe-Ser-Arg-MCA ... lgÆmL)14-nitroblue tetrazolium chloride,and 157 lgÆmL)15-bromo-4-chloro-3-indolyl phosphate.The following cell lines were tested: pancreatic cancer,HPC-Y0, HPC-Y3, HPC-Y5, HPC-Y9, HPC-Y25,HPC-YS, ... recom-binant prosemin.At pH 8.0, recombinant prosemin the most preferen-tially cleaved benzyloxycarbonyl (Z)-His-Glu-Lys-MCA, and it showed high enzymatic activity againstBoc-Gln-Ala-Arg-MCA...