... byanti-TB medication was defined as; 1) a transaminase increaseto >3 times the normal upper limit; and 2) any elevation of transaminase above basal levels in the presence of icteric hep-atitis. ... especially hepatitis and rash,is highest for pyrazinamide, and that this is associated with a female sex, an older age, birth in Asia, and HIV infection.Though we now discontinue pyrazinamide after ... factor group (advanced age, chronicliver disease, abuse of alcohol, and others), and van den Brandeet al. (31) a 22% incidence of hepatotoxicity (transaminaseincrease >5 times the basal...