... NCT00515892,NCT01086644, NCT00659425 and NCT00586924). Other RITs from our laboratory in clinical trials include the anti-mesothelin SS1(dsFv)PE38, called SS1P, for the treatment of lung cancer and mesothelioma [41,42](ongoing ... agent for the elimination of cells havebecome purposeful strides to generate the immunotox-ins of today and, we anticipate, the medicines of tomorrow. Advances in our understanding of PE and its ... catalyze the formation and breakage of disulfidebonds in proteins [63]. They are abundant not only in the endoplasmic reticulum (ER) and Golgi, but also in other intracellular locations and on the...