... Cellstransfected with expression vectors encoding ANG-PTL1, -2 , -3 , -4 or -6 secrete each ANGPTL proteininto culture supernatants [7–9], and ANGPTL2, -3 , -4 and -6 have been detected in the systemic circulation,suggesting ... 559characterized by a coiled-coil domain in the N-termi-nus and a fibrinogen-like domain in the C-terminus.Angiopoietins have a signal sequence in the N-termi-nus for protein secretion, and secreted angiopoietinfunctions ... factor-a, inter-leukin-6 and interleukin-1b) was increased in the adi-pose tissue of ANGPTL2 transgenic mice comparedwith that of wild-type mice [15]. Conversely, ANG-PTL2 null mice fed a high-fat...