... the
total amount of SLP-76 in the CD3 treated lanes. The
75-kDa protein comigrated exactly with SLP-76. These
results indicate that both the SH2 domain and the PTB-
Tyr region of Shb, are vital ... mutation in the SH2
domain affects the co-immunoprecipitation of several
tyrosine phosphorylated proteins
To further investigate the protein-interactions of the Shb...
... community pharmacists
might be the only point of contact when they had
minor aliments. Therefore, there is a need in promoting
and extending the roles of the western medicine com-
munity pharmacists ... medications. Patterns of OTC uses reflect the characteristics of populations who rely on community pharma-
cists and Chinese medicine retailers as their main point of contact wi...
... 180
ccgacctcagGCCTC CATAGgtgacacctc 9 145 1
Mouse 10 117
ctctttgcagGTTGG GTTTGgtaagtatct 10 681 1
Human 10 114/126
d
cttgtttcagGTCGC GTTGGgtgatctcaa 10 801 1
Mouse 11 120
ttcttcacagATGAG GCCCGgtgagcatca ... within the repeat region (see further) to
obtain the cDNA corresponding to the end of the repeat
region. The sense oligonucleotide NAU972 (5¢-GAGCTGC
CTGTGTTCTTGCCTCCT-3¢) was de...
... of
one strand: 1 (bio-AAAAATGGGTCAACGTGGGCAA
AGATGTCCTAGCAATGTAATCGTCTATGACGTT),
2 ( GTCGGATCCTCTAGACAGCTCCATGTTCACTG
GCACTGGTAGAATTCGGC), 3 (TGCCGAATTCTA
CCAGTGCCAGTGAAGGACATCTTTGCCCACGTTG
ACCC), ... protein. The
results suggest that the m odified pin in uences the a bility to
bind duplex DNA and is consistent with observations by
Ingleston et al. [12] showing that mutations in E...
... perturbation of the electronic absorbance
properties of the chromophore without affecting the
coordination number or the spin state of the haem-iron,
and the quenching of the
1
H-NMR relaxivity. ... linked by extended random coils. It is thus
reasonable to hypothesize allosteric conformational tran-
sition(s) occurring in HSA upon ligand binding. Note that
the flexibility o...
... ribozyme in Mn
2+
is that binding of
the cosubstrate to its site induces a conformational
change in the RNA that inhibits Mn
2+
binding at
another inhibitory site(s). It may be relevant that
in vitro-evolved ... trans-
reaction [10] that involves the free intron reacting with
5.8S rRNA (not shown). Together, these data sugges-
ted that inhibition by Mn
2+
probably involved the...
... The
incidence rates in the Netherlands have only fluctuated
around the same level since the early 1990 s. Yet, mor-
tality has been steadily declining [1].
The burden of stroke in the Netherlands is ... as
defined ex ante, and was the only one cost-effective in
the first six months after stroke in the EDISSE trial,
while the other did not comply to these criteria...
... time from the onset of illness to the
initiation of antiviral therapy was 7.4±4.17 days
(range, 1 to 22 days); 2 of the patients received anti-
viral therapy within 48 hours after the onset ...
findings are consistent with these reports. In our data
and in other studies, death was occurred mostly
young critically ill patients (1, 13, 14). But, the risk of
death increase...
... al-
lergy to egg and antibiotics. At the time of study, the
subjects had not received allergy therapy, and were
not being treated with any medication. Subjects did
not have a past history of ... able to mediate antibody depend-
ent cell mediated cytotoxicity against cancer cells in
vitro. These responses were not correlated with total
serum IgE levels. We therefore specul...