... filling a gap created by a glycine in helix aA within the SH2 domain of the phosphatase [31,46–48]. The glycine is conserved in the N- and C-terminal SH2 domains of both SHP1 and SHP2 and is required ... member of this family, CIS, was cloned as an immediate-early gene induced by several cytokines. CIS has beendemonstrated to bind to tyrosine-phosphorylated motifswithin EpoR and the IL-3 receptor, ... Matsumoto, A. , Masuhara, M., Mitsui, K., Yokouchi, M.,Ohtsubo, M., Misawa, H., Miyajima, A. & Yoshimura, A. (1997)CIS, a cytokine inducible SH1 protein, is a target of the JAK-STAT5 pathway...