Báo cáo Y học: Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides doc
Báo cáo Y học: Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides doc
... nucleotides is a general characteristic of thefamily of guanylate cyclases. This allosteric inhibition is mediated by direct interaction of adenine nucleotides with sGC, likely at the catalytic ... Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides Inez Ruiz-Stewart, Shiva Kazerounian, ... adenylate cyclases [27].Regulation of guanylate cyclases by purine nucleotides also is complex. Coupling between the ligand binding andcatalytic domains of pGCs is mediated by the KHD in thecytoplasm,...
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Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"
... status, homocysteine metabolism, and methylene tetrahydrofolate reductase genotype in rural South African blacks with a history of pregnancy complicated by neural tube defects. Metabolism. 1999;48(2):269-74. ... synthase, which uses 5-methyltetrahydrofolate as a carbon donor [6] . This donor is synthesized by the methylenetetrahydrofolate reductase (MTHFR) gene from 5,10-methylene-tetrahydrofolate [9,10]. Reduction ... were kept at -80°C till analysed. PCR-RFLP analysis The C677T MTHFR gene mutation was detected by PCR-RFLP analysis using Hinf I restriction analysis of a 198-bp polymerase chain reaction–amplified...
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Tài liệu Báo cáo Y học: Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima A new insight in the biomineralization field pptx
... jelly like substance within the shells of culturedCrassostrea gigas is frequently reported by farmers. Thisphenomenon is usually accompanied by a thickening of theshell, with spaces filled by ... samples by increasingthe aliquot size, as proposed by Gold [30].Calcium analysisCalcium analyses were performed after nitric acid hydrolysisof samples, by atomic absorption spectrophotometry, ... asreported previously [20]. The serine, threonine and tyrosinecontents of the hydrolysates were corrected for destructionduring the hydrolysis by extrapolation to zero time hydro-lysis. The amino...
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Tài liệu Báo cáo Y học: Ornithine decarboxylase-antizyme is rapidly degraded through a mechanism that requires functional ubiquitin-dependent proteolytic activity pot
... thenotion that antizyme may be degraded together with ODC,they suggest that interaction with ODC is not essential f orthe degradation of antizyme. This conclusion is supportedmainly by the experiment ... llular polyamines c omes from t heirsynthesis from amino acid precursors. In this biosynthesispathway ornithine is decarboxylated to form putrescine by the action of ornithine decarboxylase (ODC, ... a solvent, with dansylated derivatives of known polyamines serving asmarkers. The individual polyamines were visualized by UV illumination.RESULTSAntizyme is rapidly degraded by the actionof...
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Báo cáo Y học: DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells ppt
... activity is critical for C2-ceramide-induced apoptosisin PC12 cellsMutsuya Yamamoto, Takeshi Hioki, Takehisa Ishii, Sadayo Nakajima-Iijima and Shigeo Uchino*Pharmaceuticals Discovery Laboratory, ... apoptosisand necrosis. However, it is not known whether the k inaseactivity is involved in apoptosis. In the present study, weemployed PC12 cells, extensively used as a model to studymechanisms ... and physiological orpathological neuronal cell death. However, it is not knownwhether DAP kinase activity is critical for neuronal celldeath.Ceramide, generated by sphingomyelin hydrolysis,...
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Báo cáo Y học: ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) pdf
... p53,which is phosphorylated by cyclin A/cdk2 [16]. Site-directedmutagenesis procedures and the two-dimensional peptidemapping analysis have established that Ser274 in p70ik3-1 is phosphorylated by ... resembles the site in p53which is phosphorylated by cyclin A/cdk2 [16]. Wetherefore asked whether this position is the phosphorylatedFig. 3. p70ik3-1 is phosphorylated by cyclin/cdk3 in vivo. (A–C)COS7 ... cdk3-mediatedphosphorylation.Keywords: cdk3; ik3-1; phosphorylation.Mammalian G1 phase progression is regulated by G1 cyclinand cyclin-dependent kinases (cdks). Cdk4 or cdk6 is associated with D-type cyclins...
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Báo cáo y học: "Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Diseas"
... Mus, Turkey 4. Yuzuncu Yil University Faculty of Science, Department of Chemistry, Van, Turkey 5. Yuzuncu Yil University, Faculty of Medicine, Department of Cardiology, Van, Turkey Corresponding ... may be increased in patients with CAD. Key words: coronary artery disease; trace element; heavy metal; vitamin INTRODUCTION Coronary artery disease (CAD) is a leading cause of morbidity ... Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease Aysegul Cebi1, Yuksel Kaya2, Hasan Gungor3, Halit Demir4, Ibrahim Hakki Yoruk4, Nihat Soylemez2, Yilmaz...
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Báo cáo y học: "Placenta Percreta-Induced Uterine Rupture Diagnosed By Laparoscopy in the First Trimester"
... common risk factor for uterine rupture is a history of Cesarean section. Other risk factors in-clude placenta previa; high parity; advanced maternal age; and a history of endometriosis, dilatation ... decidua basalis is partially or completely absent, and the chorionic villi invade the entire myometrium up to the serosa [5]. Uterine rupture caused by placenta percreta mainly occurs during ... diagnosis in the first trimester of pregnancy. Key words: pregnancy; first trimester; uterine rupture; laparoscopy Introduction Uterine rupture due to placenta percreta is very rare, with an...
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Báo cáo y học: " Non-syndromic multiple supernumerary teeth in a family unit with a normal karyotype: case report"
... and Surgery, University of Bari, Bari, Italy 2. Department of Medical Biochemistry, Medical Biology and Physics, University of Bari, Bari, Italy 3. Department of “Head and Neck Surgery”, Hospital ... anomaly characterized by an excess in tooth number. It seems to occur more often in patients with hereditary factors concerning this anomaly: this case represents a rare form of hyperdontia, with ... hereditary factors predisposing the onset of hyperdontia, and for the consequent management by oral surgeon of family units in which the odontostomatologic anomaly was detected without any syndromic...
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