... cells,
suggesting an interplay between the two ribozymes of a twin-
ribozyme intron.
Keywords: Didymium iridis; group I intron; ribozyme; pre-
rRNA processing.
Group I introns contain a conserved set of ... result of DiGIR1 catalysis. The critical
involvement of DiGIR1 in the formation of the 5¢ end of
the RNA could be tested by the introduction of m...
... protein associated with
mammary tumors. The availability of the cDNA coding
for the peptide permitted analysis of the role of the
c subunit in the function of the enzyme. Consistent with
the fact ... from the single-
site model in that they predict the presence of two binding
sites on each functional enzyme entity. The results of many
investigations suppo...
... results as indicating the
binding of the thiol sulfur of HS-CoM to the zinc atom of
MtaA in a way that it replaces one of the nonsulfur ligands,
possibly the oxygen of coordinated H
2
O or hydroxide.
EXAFS ... in
high-quality fits. Interestingly, in Cys239 fi Ala the zinc
seems to be penta-coordinated. These results are highly
suggestive that, in the wild-type, C...
... mortal-
ity.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
PC contributed to the design of the study, obtained data,
made the analysis, interpreted ... 28-day mortality.
Background
Sepsis is a systemic inflammatory response to a confirmed
or suspected infection. Clinically, the Systemic Inflamma-
tory Response Syndrome (...
... incidence in the age
group “>70years” (N = 329; 42%). Traumas were most
common in the age group 10-29 years, dominated by
young males with 29% of the 399 situations in this
group. In the youngest ... for 11%
of the patients. The table also shows that in 26% of the
situations, the casualty clinics were directly involved in
patient care, either as final...
... distinct career pathway. Involving such physicians in medical
emergency teams will likely facilitate the dual roles of these as a
clinical outreach arm of the intensive care unit and in identifying
problems ... the
study consisted of only a 5-minute debriefing to fill out the
standardized MET form on each patient and a weekly 1-hour
Commentary
The evolving story of medic...
... revised the
manuscript. HTS and FK had full access to all the study data
and assume responsibility for the integrity of the data and the
accuracy of the analysis.
References
1. Himmelstein DU, ... at
inception (within the first day of ICU admission) was assessed
using the APACHE II score and intensity of care using the
TISS score [15,16].
Patients were classified int...
... study performed in four
year period, which included two years before and
after of the initiation of NARP in 2003. The study in-
cluded the data obtained from all of the four univer-
sity hospitals, ... restricted for the
first three days of therapy by NARP, the consumption
of these quinolones was unsurprisingly high. Besides
that the use of oral quinolones...
... the donor site is
sutured using 3/0 polypropylene. Depending on the
amount of drainage, the drain is usually removed on
the first or second postoperative day. An informed
consent explaining ... only shaved the incision line.
Several incisions, such as lazy S, inverted T,
Y- shaped, or zigzag incisions can be used. The inci-
sion is made starting from the preauricular regi...
... These interesting and pre-
viously unreported findings suggest the necessity of
multidisciplinary study designs which take into ac-
count different characteristics of the tissues involved
in ... Turkey
4. Istanbul University, Faculty of Medicine,
Department of Histology and Embryology, Istanbul, Turkey.
5. Istanbul University, Faculty of Medicine, Department of Undersea...