... Atg13, Atg17), (b) autophago-some nucleation (Atg6, Atg14, Vps15, Vps34), (c) auto-phagosome elongation (two ubiquitin-like conjugationsystems: Atg3, Atg4, Atg5, Atg7, Atg8, Atg10, Atg12,Atg16), ... shortening the lifespan. Recently, it hasbeen shown that mutations of daf-2 or eat-2 conferresistance to these tumors [44]. These findings, togetherwith the fact that mutations of daf-2 or eat-2 ... empha-size the role of DAPK in the regulation of autophagy.Although several aspects of autophagy regulationhave been discovered, further examination of the vari-ous regulatory pathways is...