Báo cáo khoa học: "What is the Minimal Set of Fragments that Achieves Maximal Parse Accuracy?" potx

... there may be several distinctderivations that generate the same parse tree. The probability of a parse tree T is thus the sum of the probabilities of its distinct derivations. Let tid be the ... the chart.4 What is the Minimal Subtree Set that Achieves Maximal Parse Accuracy?4.1 The base lineFor our base line parse accuracy, we used the now standard division of the WSJ (see Collins1997, ... includecounts of single nonheadwords: they appear in the backed-off statistics of these parsers (seeCollins 1997, 1999; Charniak 1997; Goodman1998). But our parser is the first parser that alsoincludes...

Báo cáo khoa học: Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa potx

... infor-mation about the molecular mechanism of thesepathologies. The study of GPCRs is also of outstand-ing pharmacological interest, as this family of recep-tors is involved in a wide variety of physiological ... The G51A,G51V and G89D mutants were studied in the context of the folding and packing of the TM domain togetherwith other adRP mutations in the other TM helices[20]. These studies showed that ... reduced degree of Gt activationobserved. In terms of the thermal stability, the activeconformation of the G51V mutant was less stable than the active conformation of the mutant G89D and the ability...

Báo cáo khoa học: "WHEN IS THE NEXT ALPAC REPORT DUE" ppt

... tations. Traditionally, the start of intensive work on machine translation is taken as being a memorand~n of Warren Weaver, then Director of the Natural Sciences Division of the Rockefeller Foundation, ... themselves had begun to see that the enpi- rical approach was unsatisfactory. The European projects begun in the early 1960's at Grenoble and Milan reflect this, as does the work of the ... by considering that in those years no fewer than twelve research groups were established in the US, a number of groups in the USSR ca~e into existence, most within the Academy of Sciences in...

Báo cáo khoa học: What determines the degree of compactness of a calcium-binding protein? pdf

... based on the charges of the two EF-hand domains, and the other comprising a novel procedure that is based on linker averagehydrophilicity. The linker consists of the residues that connect the domains. The ... PtICL9(< 1% of the protein length). However, the length of the linker in the set of proteins considered in the presentstudy is approximately ﬁve residues on average, which is rather short. This indicates ... QC), the net charge of the linker (Qlink) and of the entire protein (Qprot), the charge balance of the domains (|QNQC|), the absolute charge density (dQ), the value of the LAH, the number...

Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc

... is composed of residues 25–540. The overall structure of the model of IPU and the mutated residues in this study areshown in Fig. 3. To elucidate the mechanism of the substrate recognition of IPU, ... al.suggested that Glu179 is the general acid catalyst of pKa5.9,and that the adjacent Glu180 is negatively charged, raising the p Ka of the general acid catalyst [23]. I t is likely t hatcatalytic ... concentra-tion of isomaltose is effective for the induction of amylasesynthesis, the low activity of IPU may be suitable for control of this regulation.AcknowledgementsWe thank Mr Masahiro Mizuno for his...

Tài liệu Báo cáo khoa học: "Methods for the Qualitative Evaluation of Lexical Association Measures" doc

... -best list (the precision) is computed. Another measure of goodness is the proportion of TPs in the base data that are also contained in the -best list (the re-call). While precision measures the ... We distinguish between two classes:(1) Characteristics of the set of candidate dataemployed for collocation identiﬁcation: (i) the syntactic homogeneity of the base data, i.e.,whether the set ... gives the precision values of the highest ranked word combinations with): As expected from the results of otherstudies (e.g. Lezius (1999)), the precision of is signiﬁcantly lower than that of...

Báo cáo khóa học: Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using ﬂuorescence spectroscopy pptx

... noticed that the dynamics of W242 in the protein is almost as large as that of W242 in the isolatedpeptide sequence P196–267 [16]. This strongly suggests that this part of the protein is highly ... informationmainly on the dynamics of this region of the protein. Thisresidue is probably widely accessible to the solvent in AC asshown by the maximum wavelength of the ﬂuorescenceemission spectrum of 350 ... scale. Supportingthis hypothesis, the initial anisotropy at t ¼ 0 when the probe is in the presence of AC or AC–CaM is 0.25–0.3(Fig. 7A curve 2). This value is higher than that observedfor free...

Báo cáo khoa học: Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4 docx

... site of Six1 and Six4, suggesting that the DNA-binding speciﬁcity of Six1 is distinct from that of Six4. This underlies the differential regulation of common target genes by Six1 and Six4. Fur-thermore, ... binding sites of Six1 that exceed innumber those of Six4 in the promoter region.Although the expression proﬁle of Slc12a2 has notbeen precisely analysed in the context of development of the kidney ... wild-type. Theseresults indicate that Six4 can support the expression of Slc12a2 in the absence of Six1 and that the commonbinding site around +135 ⁄ +138 is important for the expression of Slc12a2,...

Báo cáo khoa học: Bacitracin inhibits the reductive activity of protein disulﬁde isomerase by disulﬁde bond formation with free cysteines in the substrate-binding domain pptx

... diminish the immunoblot signals for bacitracin at the site of PDI (Fig. 4C). These data support the view of a robustcovalent PDI–bacitracin interaction.We hypothesized that the thiazoline ring of ... ring of bacitracin A (937.33).Negative ion mode CID-TOF ⁄ TOF MS analysis of the same precursor yielded the corresponding signaturepeaks (m ⁄ z 1404.88, 1438.82 and 1470.80) of the otherpart of ... all other amino acids not involved in the crosslink by the sin-gle-letter code. The PDI peptide side of the disulﬁde bond is named R1, and the bacitracin side R2. (C) MALDI-TOF MS spectrum of...

Báo cáo khoa học: Intrabodies against the EVH1 domain of Wiskott–Aldrich syndrome protein inhibit T cell receptor signaling in transgenic mice T cells potx

... antigen. Therefore, large-scalelibraries and extensive screening are required for the selection of the antigen-speciﬁc antibody fragments. On the other hand, the antibody fragments isolated ... further the function of the WASP-EVH1 domain in the TCR signaling pathway, wedeveloped transgenic (Tg) mice that expressintrabodies that speciﬁcally bind to the WASP-EVH1domain. The cDNA fragments ... without the VHleadersequence at the N-terminal and with ⁄ without the CL(j) region behind the VLregion. None of the con-structs contained the KDEL sequence at the C-termi-nus. We compared the...

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