Báo cáo khoa học: Structure and positioning comparison of two variants of penetratin in two different membrane mimicking systems by NMR pdf
Báo cáo khoa học: Structure and positioning comparison of two variants of penetratin in two different membrane mimicking systems by NMR pdf
... Structure and positioning comparison of two variants of penetratin in two different membrane mimicking systems by NMR Mattias Lindberg, Henrik Biversta˚hl, Astrid Gra¨ slund and Lena ... importance of the positioning in the membrane. When changing the two tryptophans(residue 48 and 56) of penetratin to phenylalanines it wasshown that the translocating property of penetratin wasessentially ... [13]. In this study, we have determined a NMR solution structure of penetratin and investigated the position of penetratin in negatively charged phospholipid bicelles. Thesecondary structure of...
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Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... hypermethy-lated and maintained in a repressed state by MBDproteins [202]. As summarized in Fig. 6, repressed CGislands are likely to be maintained in an inactive state by a variety of cooperating repressive ... modulation of chromatin structure and transcription by nucleosome bindingproperties of PARP-1. Cell 119, 803–814.111 Ryoji M & Worcel A (1985) Structure of the two dis-tinct types of minichromosomes ... been accompanied by a relative decrease in thenumber of studies aimed at gaining an understanding of the structural conformation of chromatin, and thechanges in chromatin structure that accompany...
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Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx
... and C-terminal domain in red. (B) Ribbon representation of the structure of the PSI domain of barley prophytepsin [25] (N-terminal domain,blue; C-terminal domain, red). (C) Model structure of ... followed by a prosegment of about 40 aminoacids, and a N-terminal domain and a C-terminal domainseparated by an insertion comprising approximately 100amino acids, named as plant-specific insert ... present in all APs and is involvedeither in the inactivation or in the correct folding, stability and intracellular sorting of several zymogens [16], the PSI isan insertion only identified in plant...
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Tài liệu Báo cáo khoa học: Structure and membrane interaction of the internal fusion peptide of avian sarcoma leukosis virus pdf
... the N-terminal FP, it wouldbe of interest to compare the structure of the internal FP and i ts interaction w ith membrane bilayer, including in particular the structural in uence of proline. Consistentwith ... Veeramuthu,B.,Kantchev,A.B.,Wu,W.G.&Chang,D.K.(2003)Effectsofalterations of the amino-terminal gly cine of in uenza hema-gglutinin fusion peptide on its structure, organization and membrane interactions. Biochim. Biophys. ... data and the model of Matsuyama et al . [24] are suggestive of the idea thatdeeper membrane insertion induced by acidic pH facilitatesfusion of both inner and outer leaflets of fusing membranes.Comparison...
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Báo cáo khoa học: Structure and function of KH domains docx
... b2-strand), where it con-tacts both the invariant GXXG motif and the variableloop.Nucleic acid binding by tandem but independentKH domains – NMR structure of the KH3 and KH4domains of FBP in ... arrangement of mole-cules produces two protein–protein interfaces. (B) One protein–protein interface generated by two- fold NCS. (C) Other protein–protein inter-faces also generated by two- fold ... poly(C)-bind-ing proteins: a multiplicity of functions and search formechanisms. RNA 8, 265–278.32 Gamernik AV & Andino R (2000) Interactions of viralprotein 3CD and poly(rC) binding protein...
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Báo cáo khoa học: Structure and mechanism of the ThDP-dependent benzaldehyde lyase from Pseudomonas fluorescens potx
... six-stranded parallel b-sheet flanked by a varyingnumber of a-helices. Residues involved in binding of the cofactor ThDP are located at the C-terminal ends of the b-strands of Dom-c (diphosphates and ... Mg2+) and of Dom-a¢ of a neighbouring subunit (pyrimidinemoiety). The active centre is defined by the thiazoliumring of ThDP, which sits in a deep pocket opening tothe outer surface of the ... observed in both crystalstructures of BAL (Figs 6 and 7) as well as in thecrystal structure of BFD [12]. We suggest that thisapplies for all acyloin cleavage reactions of BAL.During acyloin C–C-bond...
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Báo cáo khoa học: Structure and function of N-acetylglucosamine kinase Identification of two active site cysteines pptx
... ATP-bindingsubdomains, indicating a common structure of the ATP-binding sites of the two enzymes. Interestingly, five of the sixcysteines of GlcNAc kinase had an equivalent cysteine in glucokinase, not always in ... align-ments of glucokinase and GlcNAc kinase and the commonATP-binding domain, the GlcNAc kinase was fitted into theglucokinase model using RasMol software. Figure 5 showsthe predicted structure of ... alignment of glucokinase and GlcNAc kinase. The amino acid sequences are numbered beginning with the first amino acid of theN-terminus. Both amino acid sequences share the ATP binding subdomains (Phosphate1,...
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Báo cáo khoa học: "STRUCTURE AND INTONATION IN SPOKEN LANGUAGE UNDERSTANDING*" pptx
... LF:Information Structure I I Structure ~Phonological Form( Figure 1: Architecture of Standard Metrical Phonology The involvement of two apparently uncoupled lev- els of structure in ... related to distinctions of discourse focus among the concepts and open propositions that the speaker has in mind. The proof of this claim lies in showing that the rules of combinatory grammar ... answer to the following question (a) intuitively impotes the intonational structure indicated by the brackets (stress, marked in this case by raised pitch, is indicated by capitals): (1)...
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Báo cáo khoa học: Structure and topology of the transmembrane domain 4 of the divalent metal transporter in membrane-mimetic environments docx
... DMT1-TM4 in TFE and SDS.Ó FEBS 2004 Structure and topology of TM4 of DMT1 (Eur. J. Biochem. 271) 1951 Structure and topology of the transmembrane domain 4 of thedivalent metal transporter in membrane- mimetic ... of DMT1 since thediscovery of this gene, there has so far been no structuralcharacterization of either this integral protein or a segment of it. Analysis of the structure of membrane proteins ... retained their intensities in this period. A TOCSY spectrum was then recorded thatFig. 3. Stereoview of NMR structures of DMT1-TM4 in SDS micelles and TFE. (A) Allatoms of 16 final structures of...
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Báo cáo khoa học: Structure and potential C-terminal dimerization of a recombinant mutant of surfactant-associated protein C in chloroform/methanol ppt
... tothe Ha and side chain protons. The spin systems of Lys10 and Arg11 are indicated by rectangles as both contain a second HN in the side chain. TheN-terminal Gly1 appears as a weak and very ... for small proteins [13] using thecomputer programNDEE(Spin Up, Lu¨nen, Germany).Owing to the high abundance of the amino acids valine,leucine and isoleucine in the sequence of rSP-C (FFI), ... solution structure of a recombinant mutant [rSP-C (FFI)] of the human surfactant-associated protein C(hSP-C) in a mixture of chloroform and methanol wasdetermined by high-resolution NMR spectroscopy....
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