... glu-cokinase and hexokinase I in distinct pools [3,24], orby the involvement of mechanisms, additional toGlc6P, in mediating the effects of glucokinase over-expression. As glucokinase binds ... FEBSlevels through the interaction of glucokinase with bind-ing proteins [5,6]. The glucokinase regulatory protein(GKRP) is a specific inhibitor of glucokinase [5] and also a nuclear receptor ... secondarychanges in gene expression, including up-regulation of lipogenic enzymes and down-regulation of glucokinasemRNA levels [38]. In the experimental conditions used in this study, involving incubation...