Báo cáo khoa học: K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase pdf
Báo cáo khoa học: K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase pdf
... findingssuggest that human cells contain histone H3, biotinyl-ated at K4, K9 and K18. DiscussionThis study provides evidence (a) that K4, K9 and K18 in histone H3 are good targets for biotinylation ... biotinylation by human biotinidase; (b) that K14 and K23 are relativelypoor targets for biotinylation; (c) that human cellscontain histone H3, biotinylated in positions K4, K9 and K18; and (d) that ... al. Biotinylation sites in human histone H3 FEBS Journal 272 (2005) 4249–4259 ª 2005 FEBS No claim to original US government works 4259 K4, K9 and K18 in human histone H3 are targets for biotinylation...
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Báo cáo khoa học: Characterization of sequence variations in human histone H1.2 and H1.4 subtypes pptx
... alanine at position 17 in H1.2 wasreplaced by valine, and, in Raji B lymphoblastoid cells, lysine at position173 in H1.4 was replaced by arginine. We confirmed these findings by DNA sequencing ... variants is unclear, but increas-ing evidence indicates that minor sequence variations in linker histonesmay change their binding characteristics, in uence chromatin remodeling, and specifically affect ... means of investigating the occurrence of sequencevariations within linker histone subtypes from various human tumor cell lines. By using HILIC we detectedamino acid substitutions in H1.2 and H1.4...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf
... proteins. Thus, the MEN1 ⁄ LEDGF-interactingdomain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHDdomains, the FYRN domain, the transactivatingdomain, ... DRB-sensitivity inducing factor; GSK, glycogen synthase kinase;H 3K4, histone H3 lysine 4; HMT, histone methyltransferase; MLL, mixed lineage leukemia; NELF, negative elongation factor; PI3K,phosphatidylinositol ... 2010)doi:10.1111/j.1742-4658.2010.07608.xThe increasing number of chromosomal rearrangements involving the human MLL gene, in combination with differences in clinical behavior and outcome for MLL-rearranged leukemia...
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Tài liệu Báo cáo khoa học: Domain deletions and substitutions in the modular protein evolution doc
... occur-ring in many different combinations are the P-loopnucleotide triphosphate hydrolase domain, the epider-mal growth factor (EGF) domain, the SH3 domain,the P-kinase domain and the domains involved ... percentages of domains that form autonomous,single-domain proteins are higher for domains thatundergo deletions at the termini, and lower for domains that undergo deletions at a nonterminalposition ... the termini regions are partly related todomain versatility and their ability to function outsidea multidomain protein (to form single-domain pro-teins). The events involving domain acquisition...
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Tài liệu Báo cáo khoa học: "Identifying Agreement and Disagreement in Conversational Speech: Use of Bayesian Networks to Model Pragmatic Dependencies" docx
... (BACKCHANNEL and OTHER are merged) using hand-labeled data ofa single meeting as a test set and the remaining dataas training material; for this experiment, we usedthe same training set as (Hillard ... first performed several empirical analyses in or-der to determine to what extent contextual informa-tion helps in discriminating between agreement and disagreement. By integrating the interpretation ... and last-word features that occur infre-quently and that are typically uninformative for thetask at hand. Remaining features essentially con-tained function words, in particular sentence-initialindicators...
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Tài liệu Báo cáo khoa học: "TYPE-RAISING AND DIRECTIONALITY IN COMBINATORY GRAMMAR*" pdf
... of the words in the sentence Gilbert walks are as shown in (27), before binding. Binding of string positional variables yields the cat- egories in (28). The combinatory rule of forward application ... outlined above, and file latter must be greatly constrained for English.) One very general constraint, excluding all combinations with or into NP, is included in the program, in order to force ... syntactic and a semantic object, in which symbols like S are abbreviations for graphs or terms including interpretations, as in the unification-based categorial grammars ofZeevat et al. [8] and...
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Báo cáo khoa học: Adipocyte hyperplasia and RMI1 in the treatment of obesity doc
... droplets in adipose cells,leading to an increased fat mass and ultimately result-ing in obesity.Adipocyte hyperplasia (increase in cell number) and hypertrophy (increase in cell size) are thought ... kinase-associated protein (Skp)1–Cullin-F-box protein (SCF) ubiquitin ligase (E3) complex targets cyclin-dependent kinase inhibitors for degrada-tion by the 26S proteasome and thereby regulates cellcycle ... cell-cycle-related molecules,including cyclins, cyclin-dependent kinases, their inhib-itors and the retinoblastoma protein (RB), as well asE2Fs.E2F and RB family members appear to participate in the regulation...
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Báo cáo khoa học: Improving thermostability and catalytic activity of pyranose 2-oxidase from Trametes multicolor by rational and semi-rational design pdf
... some 7 A˚to fill the active site and pack against the FAD cofactor. In the loop betweenb-strand B6 in the substrate-binding domain and strand E2 in the hinge domain, two residues appear toact, ... determined.Variant60 °C70°C75°CInactivationconstantk in, 1(min)1)Inactivationconstantk in, 2(min)1)Half-lifes1 ⁄ 2(min)Inactivationconstantk in (min)1)Half-lifes1 ⁄ 2(min)Inactivationconstantk in (min)1)Half-lifes1 ... was performed under the conditions: 95 °C for 4 min; then 30 cycles of 94 °C for 30 s, 58 °C for 30 s and 72 °C for 16 min; with a final extension at 72 °C for 10 min. Each reaction contained 1·...
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Báo cáo khoa học: Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production ppt
... cytokines in vivo and in vitro [22], by converting inactive precursors of cytokines such aspro-IL-1b and pro-IL-18 into their active forms[18,23], or by enhancing the expression of cytokinegenes ... extracellularsignal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) but notp38 MAPK. Unexpectedly, an inhibitor for JNK but not for MAPK ⁄ ERKkinase inhibited the FasL-induced AP-1 activation and IL-8 production.These ... could beinhibited by deleting or introducing the lymphoproliferation (lpr)-type pointmutation into the Fas death domain (DD), knocking down the Fas-associ-ated DD protein (FADD), abrogating caspase-8...
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Báo cáo khoa học: Cloning, expression and interaction of human T-cell receptors with the bacterial superantigen SSA ppt
... assaysEquilibrium and kinetic parameters for SSA binding todifferent TCR b chains were determined in a resonancemirror using an IAsys instrument biosensor. SSA affinity for the immobilized ... largedomains, which has been shown to b e the TCR binding site in other SAgs. Point mutation of Cys26 to Ser prevented dimerformation and allowed TCR interaction studies.Initial binding experiments ... N23, N60 and Y90 are conservedamong bacterial SAgs reactive with mouse Vb8.2, inclu dingSEC1–3, SPEA and SSA. The differences in residues C26 and Y91 in SSA compared with Y26 and V91 in SEC3,which...
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Từ khóa: Nghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)BÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP