Báo cáo khoa học: Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration pot

Báo cáo khoa học: Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration pot

Báo cáo khoa học: Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration pot

... (2005) 3661–3672 ª 2005 FEBS Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration Hong-Tao ... incubated with 1 mM of DA analogs for 24 h, and then the reaction mixtures were analyzed by means of SEC. (B) SDS ⁄ PAGE graph of the fr...
Ngày tải lên : 23/03/2014, 15:20
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Báo cáo khoa học: Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A pdf

Báo cáo khoa học: Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A pdf

... require interaction with, nor methylation, of the PP2A C subunit [17]. Little is known about the molecular basis for the interaction of the B subunits with the AC heterodimer. None of the B subunits ... sequence similarities between the families, they do have signi®cant sequence homology within each family. For example, within the B56 family, each isoform shares a...
Ngày tải lên : 08/03/2014, 10:20
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Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx

Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx

... pre-incubated for 5 min, the reaction was initiated by the addition of 500 lm (dl)-homocysteine and incubated at 37 °C for a further 30 min, unless otherwise stated. The reaction was terminated by the ... shows the superimposed structures of DHPS and 5-methyltetrahydrofolate. The model of the methyltetrahydrofolate-binding site of MetS with one molecule of...
Ngày tải lên : 19/02/2014, 05:20
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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx

Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx

... FEBS 369 Thermal unfolding transition in the absence and in the presence of the different ligands The influence of ligand binding on the thermal stability of C-LytA was studied by monitoring the CD ... but also at the active site [18]. There- fore, inhibition of the cell wall lytic activity of Pce by atropine and ipratropium could take place by interfer- ence...
Ngày tải lên : 19/02/2014, 05:20
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Tài liệu Báo cáo khoa học: Inhibition of pea ferredoxin–NADP(H) reductase by Zn-ferrocyanide docx

Tài liệu Báo cáo khoa học: Inhibition of pea ferredoxin–NADP(H) reductase by Zn-ferrocyanide docx

... 2B). The addition of 20 l M Zn-ferrocyanide in the reaction medium from the beginning of the measurement leads to the appearance of the reduced form of the enzyme, even in the presence of the ... relative to the free protein c onformations [26,50]. The protein–protein interaction also affects the microenvironments of the two prosthetic groups. In the...
Ngày tải lên : 19/02/2014, 16:20
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Tài liệu Báo cáo khoa học: Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack docx

Tài liệu Báo cáo khoa học: Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack docx

... Fe 2+ –EDTA. The presence of this metal-ion complex enhanced the inhibition observed with these enzymes consistent with the o ccurrence of radical- mediated reactions. Overall, these studies ... removal of H 2 O 2 before the peroxides were u sed in other experiments. Omission of the rose bengal, photolysis in the absence of O 2 , or incubation of complete samples...
Ngày tải lên : 21/02/2014, 03:20
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf

Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf

... immunoreactivity (IR). The staining was semi- quantitatively evaluated by assigning a score for the inten- sity of the IR and for the proportion of cells positively stained. The intensity of IR (intensity ... cells. Therefore, the promoter sequence of MDR-1 ()136 to 10) was amplified, and the luciferase reporter assay was performed to investigate the transcription...
Ngày tải lên : 07/03/2014, 03:20
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Báo cáo khoa học: Inhibition of an iron-responsive element/iron regulatory protein-1 complex by ATP binding and hydrolysis docx

Báo cáo khoa học: Inhibition of an iron-responsive element/iron regulatory protein-1 complex by ATP binding and hydrolysis docx

... hydrolysis of [ 32 P]ATP[cP] in the presence of 0–400 ng of IRE (Fig. 8). Compared to the amount of ATP hydrolyzed with 400 ng of IRP alone, addition of IRE increased the release of inorganic ... complex formation. Further- more, ATP-cS, but not AMP-PNP, inhibited IRP–IRE binding in extracts from fibroblasts treated with the analogs in culture [41]. Therefore, the...
Ngày tải lên : 07/03/2014, 09:20
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Báo cáo khoa học: ` Inhibition of human ether a go-go potassium channels by 2+ Ca ⁄calmodulin binding to the cytosolic N- and C-termini potx

Báo cáo khoa học: ` Inhibition of human ether a go-go potassium channels by 2+ Ca ⁄calmodulin binding to the cytosolic N- and C-termini potx

... only by an excess of the same, un- labeled peptide, but also by an excess of the unlabeled peptide from the other binding sites (data not shown). The validity of the results obtained for the binding of ... channels are formed by 4 of such subunits involving the C-terminal assembly domain. (C) Magnified sections of the peptide array: The numbers indicate t...
Ngày tải lên : 07/03/2014, 12:20
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Báo cáo khoa học: Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives pdf

Báo cáo khoa học: Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives pdf

... generated in the intestinal scrapings by a-amylase present in the hetero- geneous sample or by activity in the C-terminal domain of the full-size protein, thereby accounting for the inhibition by ‘acarbose’ ... 80% of the maltase activity, while MGA accounts for all glucoamylase activity, 20% of the maltase activity, and 1% of the sucrase activity [10]. Tog...
Ngày tải lên : 07/03/2014, 12:20
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