... man [8,9]. In the verteb-rate lens, the b and c crystallins together account for the majority of the soluble proteins (the other majorfamily being the a-crystallins, members of the smallheat-shock ... essen-tially an outlier from both b and c families.Overall, these data show a broader and more com-plex view of the evolution of the bc superfamily in the vertebrate eye and the adaptive ‘choices’ made ... Notre Dame, IN, USAMuch of the complexity and diversity of life arisesfrom the multiplication and evolution of gene famil-ies, increasing the functional repertoire of the gen-ome. By gene duplication,...