Báo cáo khoa học: Anti- and pro-oxidant effects of quercetin in copper-induced low density lipoprotein oxidation Quercetin as an effective antioxidant against pro-oxidant effects of urate potx
... searches of b-amino acids were
initially carried out at intervals of 30° for each torsion angle
/, h,andw and were subsequently refined by varying /, w
angles in intervals of 10° and setting h angle ... Torrens, Y., Beaujouan, J C. & Glowinski, J. (1993)
Importance of the leucine side-chain to the spasmogenic activity
and binding of substance P analogues. Int. J. Peptide...
... Anti- and pro-oxidant effects of quercetin in copper-induced low
density lipoprotein oxidation
Quercetin as an effective antioxidant against pro-oxidant effects of urate
Paulo Filipe
1,2
, ... that
•
UH
–
wouldalsobe
involved in the pro-oxidant action of urate. Interestingly,
at high Cu
2+
concentration, in the presence of 0.5 l
M
querce...
... area of the White Moun-
tains of California. Details of animal holding, feeding and
hibernation were described in [15]. All possible measures
were taken to minimise pain and discomfort during animal
euthanasia ... stability of
plasma glucose levels [1,3,4]. In hibernators, the aci-
dotic conditions found in muscle during hibernation
can lead to an increase in histidine p...
... UK
Horseradish peroxidase (HRPC) is a member of class
III of the plant peroxidase superfamily and is cap-
able of utilizing hydrogen peroxide to oxidize a wide
range of phenols, anilines and other synthetic ... features can also exert an important
in uence in determining the electronic structure of the haem pocket. To
extend our understanding of the significance of proxi...
... by:
hE
INT
i¼E
min
complex
þ
N
complex
k
B
T
2
À E
min
protein
À
N
protein
k
B
T
2
À E
min
ligand
À
N
ligand
k
B
T
2
ð2Þ
and as N
complex
¼ N
protein
+N
ligand
,
hE
INT
i¼DE ¼ E
min
complex
À E
min
protein
À ... reduction in the K
i
for the
inhibition of AdoHcy hydrolase and a corresponding
25- and 13-fold decrease in the inhibition of HIV-1 A012
and A018 p24 antigen in PB...
... activities of donepezil and
other cholinesterase inhibitors on acetylcholinesterase
and butyrylcholinesterase in vitro. Methods Find Exp
Clin Pharmacol 22, 609–613.
28 Papandreou I, Cairns RA, Fontana ... Japan
Introduction
Our previous studies showed that an oral low dose of
donepezil, an acetylcholinesterase inhibitor and anti-
Alzheimer’s disease drug, prevented ventric...
... of neu-
rolysin and TOP was reported using internally quenched
fluorescent (IQF) peptides derived from bradykinin [5] and
neurotensin [6]. An outstanding feature of the hydrolytic
activities of ... unspecific
cleavage of other proteins and it is of particular relevance
for TOP and neurolysin as they are not expressed as inactive
precursors and they are present in hig...
... inducer of
neovascularization, and plays an important role in
tumor growth [5]. Eosinophil-derived neurotoxin
(RNase 2) and eosinophil cationic protein (RNase 3)
have antibacterial and antiviral activities. ... regarding a new class of
surrogates for the phosphoryl group.
Results and Discussion
Sulfonimides as inhibitors of RNase A
We began by determining the ability of...
... activity and is measured at saturating concentrations of IMP and sub-saturating concentrations of inosine. The K
50
for ATP was
measured as phosphotransferase activity, while for Mg
2+
, it was measured ... behav-
iour of recombinant wild-type enzyme in the presence of
ATP and Mg
2+
as an activator and P
i
as an inhibitor.
Figure 5 shows that the enzyme exists and...
... with guanine and hypoxanthine
bases, respectively, indicating that Asp137 functions as
a catalytic base [12]. However, a tight binding of N7
of the purine base and Asp137 was observed in HPRT
in ... PRTFDC1 and hypoxanthine. (B) HPRT
and hypoxanthine. (C) PRTFDC1 and
guanine. (D) HPRT and guanine.
Table 2. K
m
and V
max
values for Hx and G in the presence of 1 mM...