... solution, with unfolding of the protein over time leadingto aggregation and progressive truncation from the C-terminus. Light scat-tering, MS, and size-exclusion chromatography data indicated ... Stein Eye Institute, University of California Los Angeles School of Medicine, Los Angeles, CA, USA5 School of Biological and Biomedical Sciences, University of Durham, UKThe vertebrate lens is ... partial unfolding, increased exposure of hydrophobic regions, and enhances its susceptibility to proteolysis, thusreducing its solubility and promoting its aggregation and complexationwith...