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Báo cáo khoa học: Correlation between functional and structural changes of reduced and oxidized trout hemoglobins I and IV at different pHs doc

Báo cáo khoa học: Correlation between functional and structural changes of reduced and oxidized trout hemoglobins I and IV at different pHs doc

Báo cáo khoa học: Correlation between functional and structural changes of reduced and oxidized trout hemoglobins I and IV at different pHs doc

... by dimerization[6]. Figure 4 shows the peroxidase activity of iron(II)- and met-forms of HbI and HbIV. It is evident that the enzymaticactivity decreases according to the order iron(II)-HbIV ... Correlation between functional and structural changes of reduced and oxidized trout hemoglobins I and IV at different pHs A circular dichroism studyRosita Gabbianelli1, Giovanna Zolese2, ... Enrico Bertoli2 and Giancarlo Falcioni11Dipartimento di Biologia M.C.A., Universita`di Camerino, Camerino, Italy;2Istituto di Biochimica, Facolta`di Medicina,Universita`Politecnica...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

... confident of three findings: (a) Polyols,amino acids and amino acid derivatives are idealosmolytes, for they neither perturb the denaturationequilibrium nor affect the functional activity undernative ... nativeconformational equilibria towards the most compactprotein species within native state ensembles [32,37,38].The variation in the effect of stabilizing osmolytes inmodulating the catalytic ... there is noperturbation of the denaturation equilibrium and, hence, there is no increase in catalytic efficiency in thepresence of this group of osmolytes. Interestingly,there is a linear relationship...
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Báo cáo khoa học: Correlation between conformational stability of the ternary enzyme–substrate complex and domain closure of 3-phosphoglycerate kinase potx

Báo cáo khoa học: Correlation between conformational stability of the ternary enzyme–substrate complex and domain closure of 3-phosphoglycerate kinase potx

... domain were also studied.The coincidence of the calorimetric and fluorimetric heat transitions in allcases indicated simultaneous, highly cooperative unfolding of the twodomains. This cooperativity ... one-step irreversiblenative fi unfolded denaturation model (similar to thefindings in Fig. 2A). This deviation may influenceslightly differently the calorimetric and fluorimetricdetection of unfolding. ... cooperativity:conserved features of the interdomain regionIn order to rationalize the structural basis of the highlycooperative domain–domain interactions, indicated byprevious and present calorimetric data, we...
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Báo cáo khoa học:

Báo cáo khoa học: "Correlation between ROUGE and Human Evaluation of Extractive Meeting Summaries" pptx

... workAutomatic summarization evaluation can be broadly clas-sified into two categories (Jones and Galliers, 1996): in-trinsic and extrinsic evaluation. Intrinsic evaluation, suchas relative utility ... effective-ness of a summarization system on other tasks. In thisstudy, we concentrate on the automatic intrinsic summa-rization evaluation. It has been extensively studied intext summarization. ... reportedthat ROUGE-1 (unigram match) scores have low correla-tion with human evaluation in meetings.In this paper we investigate the correlation between ROUGE and human evaluation of extractive meetingsummaries...
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Báo cáo khoa học: Transcript profiling reveals diverse roles of auxin-responsive genes during reproductive development and abiotic stress in rice pdf

Báo cáo khoa học: Transcript profiling reveals diverse roles of auxin-responsive genes during reproductive development and abiotic stress in rice pdf

... analysis revealssimilarities and variations in genetic programscontrolling pollination ⁄ fertilization and stressresponses in rice (Oryza sativa L.). Plant Mol Biol 59,151–164.63 Jain M, Nijhawan ... results provide evidence for a probable role of auxin-responsive genes in reproductive development and abiotic stress signaling in rice.Results and DiscussionIdentification and overview of auxin-responsivegenesPreviously, ... transition, floral organdifferentiation and development, indicates their func-tional similarity. It has been demonstrated that anthersare the major sites of high concentrations of free auxinthat...
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Báo cáo khoa học: R120G aB-crystallin promotes the unfolding of reduced a-lactalbumin and is inherently unstable ppt

Báo cáo khoa học: R120G aB-crystallin promotes the unfolding of reduced a-lactalbumin and is inherently unstable ppt

... solution, with unfolding of the protein over time leadingto aggregation and progressive truncation from the C-terminus. Light scat-tering, MS, and size-exclusion chromatography data indicated ... Stein Eye Institute, University of California Los Angeles School of Medicine, Los Angeles, CA, USA5 School of Biological and Biomedical Sciences, University of Durham, UKThe vertebrate lens is ... partial unfolding, increased exposure of hydrophobic regions, and enhances its susceptibility to proteolysis, thusreducing its solubility and promoting its aggregation and complexationwith...
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Báo cáo y học:

Báo cáo y học: "Multivariate explanatory model for sporadic carcinoma of the colon in Dukes’ stages I and IIa"

... 19.9 is a tumour-associated antigen that is present in tissues that contain mucin or in the circulation, and that is located in the sialylated Lewis A blood group antigen [16-18]. The individuals ... HDL-high density lipoprotein. DISCUSSION We have made an investigation to try to vali-date a multivariate explanatory model of the diagno-sis of SCRC in Dukes’ stages I and IIa using non-conditional ... direction with an OR of 0.986, all of them reaching statistical significance (p<0.05). It is possible to affirm that this adjusted and definitive model has displayed a level of validity of...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

... located in the C-termi-nal region. The C-lobe of protein kinases mediates theinteraction with activators, substrates and regulatorysubunits, implying that the KIND domain, an atypicalnoncatalytic ... otherKIND-containing proteinsTo examine the dendrite localization signal domains inv-KIND, we first investigated the subcellular localiza-tion of eight different Flag epitope-tagged v-KINDderivatives ... protein kinase regulatory subunitRII binding domain, the central domain (CD) and the microtubule-binding domain (Fig. 3A). To deter-mine the v-KIND-binding region in MAP2, we firstdivided MAP2 into...
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Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

... rhodamine uptake. BecauseMRP-1 is inhibited by MK571 and is an MRP that isrelatively abundant in untreated ‘sensitive’ cells [4], itis a likely candidate for mediating innate resistance inthese ... 555 nm and an emission wavelength of 575 nm. Inhibition of the NBD-Cl-sensitive efflux allowed the uptake of TMRM and its quenching within the cells. Right: the various cell linesindicated in the ... rhodamine dyes, and possibly drugs such as doxorubicin, from achieving equilibration of their concentration in the cytoplasm with their concentration in the exter-nal medium. The protection provided...
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Tài liệu Báo cáo khoa học: Relationships between structure, function and stability for pyridoxal 5¢-phosphate-dependent starch phosphorylase from Corynebacterium callunaeas revealed by reversible cofactor dissociation studies doc

Tài liệu Báo cáo khoa học: Relationships between structure, function and stability for pyridoxal 5¢-phosphate-dependent starch phosphorylase from Corynebacterium callunaeas revealed by reversible cofactor dissociation studies doc

... enzymeactivity upon the apofiholo conversion is determined bycofactor structure, the process of dime rization is relativelyindiscriminate in respect to structural modifications of PLP.Induction of structural ... unstableconformation. The detailed e xamination of the stepsinvolved in subunit d issociation and reassociation willcontribute to a better understanding of the dimerizationprocess per se and the role of ... fromCorynebacterium calluane (CcStP) was dissociated intonative-like folded subunits concomitant with release of pyridoxal 5¢-phosphate and l oss o f activity. The inactivationrate of CcStP under resolution...
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