Báo cáo khoa học: Role of gangliosides in the association of ErbB2 with lipid rafts in mammary epithelial HC11 cells docx

Tài liệu Báo cáo khoa học: "An API for Measuring the Relatedness of Words in Wikipedia" docx

... accessed using robust Open Source applications,e.g. the MediaWiki software5, integrated within aLinux, Apache, MySQL and PHP (LAMP) softwarebundle. The architecture of the API consists of the following ... calling Perl routines from the Java API.Perl routines take care of the bulk of querying ency-clopedia entries to the MediaWiki software (which in turn queries the database) and efﬁciently parsing the ... based on the linkstructure of the articles);3. computing paths in the Wikipedia categoriza-tion graph between the categories the articles areassigned to;4. returning as output the set of paths...

Tài liệu Báo cáo khoa học: "HOW DO WE COUNT? THE PROBLEM OF TAGGING PHRASAL VERBS IN PARTS" docx

... assignment. In the case of to gun down the ambiguity of to is enhanced by the ambiguity of gun, and a mistake in tagging gun will automatically lead to an incorrect tagging of to as ... between the verb and the particle in order to optimize the performance of the tagger. 3. THE EXPERIMENT 3.1. DATA The first step in testing this hypothesis was to evalu- ate the current ... sample of the pairs examined in tile first column, PARTS performance for each pair in tile second, and the results of assuming a verbal tag in the third. (The "choice" colunm is explained...

Báo cáo khoa học: Amino acid limitation regulates the expression of genes involved in several speciﬁc biological processes through GCN2-dependent and GCN2-independent pathways ppt

... that the mecha-nism underlying the recognition of protein quality actsthrough the sensing of free circulating amino acidsresulting from the intestinal digestion of proteins [4,5].Another ... contributeto these multistep processes, including the metabolicconditions of the cell, nature of the stimulus, RNAbinding factors and the sequence of the target mRNA[35].Another amino acid sensing ... the level of transcription andmRNA stability. The molecular mechanisms involved in the regulation of GCN2-independent genes are notunderstood. We investigated the role of transcription in the...

Báo cáo khoa học: Amino acid residues on the surface of soybean 4-kDa peptide involved in the interaction with its binding protein potx

... S.H. & Tager, H.S. (1987) Role of the COOH-terminal B-chain domain in insulin–receptor interactions:identiﬁcation of perturbations involving the insulin mainchain.J. Biol. Chem. 262, 12054–12058.20. ... role in binding to the 43-kDa protein. Role of amino acids in the 4-kDa peptideBy alanine-scanning mutagenesis of the 4-kDa peptide, weidentiﬁed that 13 amino acids play an important role in ... impairment in binding of the 43-kDa protein, i.e. greater than a fourfold increase in the Kdvalue. Three of the 13 variants (Asp2, Asn4 and Ser8)are located in the N-terminus of the 4-kDa peptide...

Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modiﬁcations ppt

... to the nuclei of a neuron subpopulation, with no binding to the nuclei of glial cells. This result suggests that neu-rons display selective GlcNAc-binding proteins, anintriguing result in the ... ligand is involved in the initial homing of leuko-cytes to sites of in ammation [73,74]. The binding of PSGL-1 to P-selectin is largely due to two PTMs,namely an O-glycan that contains tetrasaccharidesialyl-LewisX, ... brain tissue both in vitro and in vivo,including in the detection of cerebral malaria.Retooling of this reporter system also allowed sys-tematic investigation of the role of GlcNAc-ylation...

Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx

... conclusion, the identiﬁcation of new metabolites of vitamin D3 made by the action of P450scc willenable us to proceed with further biological testing of these compounds and the investigation of whether ... monohydroxyvi-tamin D3.Because cyclodextrin provides an artiﬁcial means of holding vitamin D3 in solution, we also examined the metabolism of vitamin D3 incorporated into the membrane of phospholipid vesicles, ... metabolism of vitamin D3 in phospho- lipid vesicles. Vesicles containing 0.2 mol vitamin D3Æmol)1phos-pholipid were incubated with 2.0 lM P450scc for the indicatedtimes. (A) Consumption of vitamin...

Tài liệu Báo cáo khoa học: "A Practical Solution to the Problem of Automatic Word Sense Induction" doc

... that these vectors reflect the sum of the contextual behavior of a word’s underlying senses, i.e. they are mixtures of all senses occur-ring in the corpus. However, since reconstructing the ... mixtures of all its senses. Inducing a word’s senses therefore involves the difficult problem of recovering the sense vectors from the mixtures. In this paper we argue that the demixing problem ... namely the problem of data sparseness, could be mini-mized by looking at only the three main di-mensions of the context matrices. 1 Introduction The topic of this paper is word sense induction,...

Tài liệu Báo cáo khoa học: "UNDERSTANDING NATURAL LANGUAGE INSTRUCTIONS: THE CASE OF PURPOSE CLAUSES" doc

... affects the execution of the enabling action. Consider the difference in the interpretation of to in go to the mirror, depending upon whether the action to be enabled is seeing oneself or carrying ... requires the assumption that the referent of the urn of coffee is in the other room. Schematically, one could represent this kind of inference as in Fig. 2 -/~ is the goal, ~ the instruction ... nothing is asserted with regard to their happening in the world. rAs I mentioned earlier in the paper, the Greek symbols on the other AnimNL modules for 1) parsing the in- put and providing...

Tài liệu Báo cáo khoa học: "Incorporating Context Information for the Extraction of Terms" pdf

... terms of number of words, f(a) the frequency of a in the corpus, Ta the set of candidate terms that contain a, P(T~) the number of these candidate terms. At this point the incorporation of the ... these strings, C-value is calculated resulting in a list of candidate terms (ranked by C- value as their likelihood of being terms). The length of the string is incorporated in the C-value ... where the verbs that appear with terms can even be domain independent, like the form called of 501 the verb to call, or the form known of the verb to know, which are often involved in...

Báo cáo khoa học: Flexibility and communication within the structure of the Mycobacterium smegmatis methionyl-tRNA synthetase Henrik Ingvarsson and Torsten Unge potx

... Pro155, the main-chain amide groups of Ile128 and Arg129.Despite these differences in the coordination of the res-idues in the tip, the fold of the loop is strikingly simi-lar. The rmsd for the ... byforming a tight interaction with the catalytic domain.Binding of adenosine to the methionine complexinduced a 1.8 A˚shift of the entire KMSKS domain in the direction closer to the catalytic ... the KMSKS domain in yellow and the anticodon domain in blue. The intervening helices a2 and a8 in the catalytic domain are coloredcyan. The linking p-helix a13 between the KMSKS domain and the anticodon...

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