... analyzed
recruitment of factors to the a-globin gene locus dur-
ing the differentiation of erythroid cells. The regula-
tory elements located upstream of the a-globin genes
also appear to initiate the ... activation of the gene locus.
However, in contrast to the b-globin LCR and the
VpreB1 and k5 gene locus, the a-globin regulatory ele-
men...
... Recruitment of coregulator complexes to the b-globin gene
locus by TFII-I and upstream stimulatory factor
Valerie J. Crusselle-Davis, Zhuo Zhou, Archana ... to the b-globin gene. Together,
these data demonstrate that the antagonistic activities of upstream stimula-
tory factor and TFII-I on b-globin gene expression are mediated at least in...
... information), and the 5¢-termini of the NtFAD3
transgene cDNAs were distributed in the same region
of the transgene sequences, suggesting that the NtFAD3
transgene was transcribed under the control of the
same ... for the endogene). In contrast, the level of
nuclear transcripts of the NtFAD3 transgene was
reduced to 0.75 ± 0.20 of those of S44 plants
(mea...
... available.
To analyse further the composition of the PS1 complex,
samples with high expression of PS1 complex were selected
for further study. BN/PAGE gel bands corresponding to the
region of PS1 complex ... [19] to analyse further and characterize endo-
genous native complexes from mouse and human brain
tissue and from the neuroblastoma line SH-SY5Y (SY5Y).
Experi...
... binding to the catalytic domains of PAH and TH
Docking of the native cosubstrate BH
4
into the crystal
structure of the PAH catalytic domain yielded a total of
286 conformations. Out of these, ... displayed the expected coordination of
the tyrosine aromatic ring towards the iron atom. However,
the hydroxyl group of the aromatic ring was placed trans to
Hi...
... hand-offs
offset the reduced errors associated with better-rested care
providers? As noted by the authors, their intervention took
place in a system that was designed to minimize the impact
of ... calculated to be 80%, not 90%.
In addition, there is one error in the description of the
limitations that we would like to point out. Dr Sarani and Dr
Alarcon note:
“There we...
... coadministered (Fig. 4C).
Taken together, these results indicate that the location
of the protective action of oleate was upstream of ER
stress activation.
Whether the protection offered by oleate was specific
for ... Interestingly, the interruption of TAG synthe-
sis preceded the appearance of toxic effects, supporting
the notion that it constitutes the initiating...
... to only
one acceptor molecule until the release of the final
product. Another mechanism is suggested by Mooser
et al. on the basis of the identification of the active site
and the similarity with ... addition, the kinetics of
the acceptor reactions appeared to be similar between
GS and GSGB.
Kinetic simulation of GTF glucan synthesis
To explain the time c...
... helices in the
large domain and two b-strands in the small domain. The
active site is at the bottom of the barrel and is totally
Correspondence to M. J. Kornblatt, Department of Chemistry and
Biochemistry, ... 251, 775–
780]. The UV spectra of the high pressure forms of the
Mg
2+
- and apo-forms of enolase are identical and distinct
from the spectrum o...
... 4-methoxyacetophenone (III)
(Table 2). The percentage of
18
O incorporated was estima-
ted by the ratio of the M
+
/(M
+
+2)peaksinthemass
spectrum of the products. Neither the diarylpropane (I) nor
the ... detectable amount of the
a-keto diarylpropane (X) was produced in the absence of
Tween 80 (Table 1). To determine possible pathways for the
oxidation of...