Báo cáo khoa học: A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G1 cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors pdf

... primer, 5¢-ACACTGGCGGCCTGACAAAG-3¢,5¢ primer, 5¢-AGCTCGTAGTAAGGGCCAATGAATGTTCT-3¢; p27: 3¢ primer, 5¢-CAAAACCGAACAAAAGCGAAACGCCA-3¢,5¢ primer, 5¢-CAACCCATCCAAATCCAGACAAAAT-3¢. All constructs ... Shimano H, Nakakuki M, Matsuzaka T,Nakagawa Y, Yamamoto T, Sato R, Takahashi A, Sone H, Yahagi N et al. (2005) Lipid synthetic tran-scription factor SREBP- 1a activates p21WAF1 ⁄ CIP1, a universal ... 2582–2588.14 Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N,Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y,Iizuka Y, Ohashi K et al. (2002) Transcriptional activi-ties of nuclear SREBP- 1a) 1c, and -2...

... reverse, 5¢-AGGAGCCTTTGGTGAGTTCAATT-AT-3¢; OGG1 forward, 5¢-CGCTATGTATGTGCCAGTGCTAAA-3¢; OGG1 reverse, 5¢-CCTTAGTCTGCGATGTCTTAGGCT-3v; GAPDH forward, 5¢-GACAACTTTGGTATCGTGGAAGG-3¢; and GAPDH reverse, ... lg of total RNA, with a ReverTra Ace reverse trans-criptase kit (Toyobo Co. Ltd. Osaka, Japan). The RNA andcDNA of each sample were assayed with the gene quantpro dna ⁄ rna calculator to assess ... TI, Kanki T, Muta T, Ukaji K, Abe Y, Nakay-ama H, Takio K, Hamasaki N & Kang D (2003)Human mitochondrial DNA is packaged with TFAM.Nucleic Acids Res 31, 1640–1645.40 Hayashi Y, Yoshida M,...

... 5¢-AGTTTCGCTCTTGTCTCCCAG-3¢; P1 antisense, 5¢-ATGGCGAAACCCTGTCTCTAC-3¢; P2 sense, 5¢-AGACAGCCGTTTTACACGCAG-3¢;P2 antisense, 5¢-CACCGAGAAATCGAAATCACC-3¢;P3sense, 5 ¢-TAGGAAGGTTGTATCGCGGAGG-3¢; and P3antisense, ... Quantitativeestimation of p16 mRNA level. Cells were transfected with HDAC3 or HDAC4 vector. Total RNA was isolated and reverse transcribed, andp16 mRNA was measured by real-time PCR. b-Actin was used as an ... histone acetyltransferase; HDAC, histone deacetylase; RNAi, RNA interference; SAHF, senescence-associated heterochromatin foci; SA-b-gal, senescence-associated b-galactosidase; siRNA, small interfering...

... Haematolog-ica 89, 1332–1340.42 Naito K & Fujikawa K (1991) Activation of humanblood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa ... FXI-deficient plasma as sub-strate (Hemoliance, Salt Lake City, UT). FXI antigen wasmeasured by an ELISA based on a goat anti-human FXIaffinity purified IgG as capture antibody and a goat anti-human FXI ... 88,2611–2618.30 Solera J, Magallon M, Martin-Villar J & Coloma A (1991) Identification of a new haemophilia BM caseproduced by a mutation located at the carboxy terminalcleavage site of activation peptide....

... for amplification of the NOX4 promoter were asfollows: 5¢-AACAATCAGTCTAAAAGAGCTGTGTCTTCT-3¢ (forward for GC-box1), 5¢-CTCCAAAATACTGGCAAACATGTGAACAAT-3¢ (reverse for GC-box1), 5¢-TGAGTGGGCAGAGCTGACCCGGTGCGGGT-3¢ ... Sp3 transcription factor is crucial for transcriptionalactivation of the human NOX4 geneMasato Katsuyama1,2, Hideyo Hirai3, Kazumi Iwata2, Masakazu Ibi2, Kuniharu Matsuno2,Misaki Matsumoto2and ... the treatment of fibrosis, cancers, and cardiovascular and metabolicdiseases.Materials and methodsMaterialsAn antibody against Sp1 was purchased from Active Motif(Carlsbad, CA, USA). Antibodies...

... contain a carbohydrate chain; ApoC3-1, ApoC3 with a GalNAc-Gal-sialic acid carbohydrate chain; ApoC3-2, ApoC3 containing the carbohydrate of ApoC3-1 plus an additional sialic acid residue;DPPase, ... background of at least1000 subjects was typical of the American Midwest with 90% of European ancestry and  5% each of Africanand Asian ancestry. An exception was the targeted analysis of ... persons of AmericanIndian or Mexican ancestry. MS ⁄ MS analysis revealed that the alterationconsisted of a T45S variation. The methyl group of T45 forms part of the lipid- interacting surface of ApoC1....

... & Brade, H. (1994) Preparationand structural analysis of oligosaccharide monophosphatesobtained from the lipopolysaccharide of recombinant strains of Salmonella minnesota and Escherichia coli ... Gram-negative bacteria, and their adaptability tomany different pollutants [1].Pseudomonas stutzeri OX1 is a Gram-negative bacteriumisolated from the activated sludge of a wastewater treatmentplant, ... Scognamiglio, R., Viggiani, A. , Izzo, V., Passaro, I.,Notomista, E., Piaz, F.D., Amoresano, A. , Casbarra, A. , Pucci, P.& Di Donato, A. (2002) Expression and purification of therecombinant...

... mRNA accumulation in transgenic Arabi-dopsis thaliana. Plant Cell Physiol. 42, 1174–1180.46. Hacham, Y., Avraham, T. & Amir, R. (2002) The N-terminalregion of Arabidopsis cystathionine gamma-synthase ... can be calculated as follows: ELISA assays werecarried out using rabbit antibodies raised against therecombinant proteins [12,14] and purified proteins asstandards. We measured that an extract ... Jcystathioninedecreasingand JThrincreasing as the concentration of AdoMet wasincreased. Half changes in Jcystathionineand JThrareobtained for a concentration in AdoMet of about15 lM, i.e. for a value...

... (A) Fractionation PCR. A partial fragment of the mitochond-rial large subunit ribosomal RNA (23S rRNA) was amplified by PCR,using fraction samples that contained equal amounts of protein. Lane, ... kb. To date, there has been no evidence of an association between mitochondria and Tetrahym-ena cell death, and mitochondrial homologues of mam-malian apoptosis factors, such as AIF, have not ... mitochondrial intermembrane spaceand translocates to the nucleus after its release frommitochondria. Apoptosis-inducing factor causes chro-matin condensation and degrades DNA into fragments of sizes...

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...