Báo cáo khoa học: Acute intermittent porphyria – impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties pdf
Báo cáo khoa học: Acute intermittent porphyria – impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties pdf
... identification and expression of exonic mutations in the hydrox-ymethylbilane synthase gene. An initiation codon mis-sense mutation in the housekeeping transcript causes‘variant acute intermittent porphyria ... were offered screening for the individual mutation.To study the impact of the various mutations on protein structure and functional consequences, mutatedproteins were expressed in E. coli and enzymatic ... Thus, the effect of a mutation can be evaluated by observing the function of the residue conserved in the structure and by assessing its conservation in the sequence in relationto structure and...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
... roles in the induction of mitochondria-mediated apoptosis and the inhibition of invasion, along with the downregulation of matrix metalloproteinase expression. In addition, byusing the calcium indicator ... cells on the bottom of the Matrigel-coated inserts. The number of invasive cells wasdetermined by counting the number of stained cells and then normalizing it to the number of control (Cont) ... from the ER has been described as one of the mechanisms of this regulation. On the basis of the above findings, our research provides new insights into the role of exon 9 in the regulation of apoptosis...
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Tài liệu Báo cáo khoa học: DNA strand exchange activity of rice recombinase OsDmc1 monitored by fluorescence resonance energy transfer and the role of ATP hydrolysis pptx
... function of reac-tion time, at a fixed concentration of protein, by varyingnucleotide cofactor conditions. The reaction was the fastest when it contained ATP, where within about10 0–1 50 s the ... function of OsDmc1 protein concentration (Fig. 4A, lines 2 and 3). How-ever, at concentrations higher than 2.5 lm OsDmc1,there was only an increase in the rate, but no furtherincrease in the ... some criticalsteps in the conversion of inactive forms of protein tothat of active forms. It is interesting and intriguing tonote that in the absence of any nucleotide cofactor,OsDmc1 leads...
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Tài liệu Báo cáo khoa học: "A Multimodal Interface for Access to Content in the Home" pdf
... the pen. In the remote control version, the recog-nizer can also be activated using a button on the remote control. The main section of the search display (Figure 2) contains two panels. The ... used the tablet and then the re-mote control and the other half used the remote 1 Here we report results for the wireless microphone only. Analysis of the other microphone conditions is ongoing. ... version of the system. 5 Conclusion With the range of entertainment content available to consumers in their homes rapidly expanding, the current access paradigm of direct manipulation of complex...
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Báo cáo khoa học: Evidence for two different electron transfer pathways in the same enzyme, nitrate reductase A from Escherichia coli potx
... reduction and oxidation of the cytochromehemes with analogues of physiological quinones, usingmenadione as an analogue of menaquinone and duro-quinone as an analogue of ubiquinone, and comparing ... four kineticphases in the reduction of the hemes by menaquinol.According to the quinone type used, the two hemes of the cytochrome are probably involved in the transfer of electrons from the ... showing cross-inhibition of menadiol and duro-quinol on the binding of these electrons donors to the cytochrome b of nitrate reductase [13].These results with HOQNO explain those of Rotheryet...
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Báo cáo khoa học: Distinguishing between different pathways of bilayer disruption by the related antimicrobial peptides cecropin B, B1 and B3 pptx
... showed the concentration-dependent effect of bilayer disruption, based on the different thermotrophicphase behaviours and the shapes of the thermal phase-transition curves obtained. The kinetics of ... location, and aggregation state of peptides in their lipid-bound state by analysis of the thermaltransitions that these peptide–lipid interactions generate and has been shown to provide valuable information ... the manufacturer’s software and protocols. A diagram of the construction of the biosensor surface is shown in Fig. 1.Binding of peptides to the immobilized liposomes causes anincrease in resonance units...
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Báo cáo khoa học: Modular metabolic control analysis of large responses in branched systems – application to aspartate metabolism potx
... upmod-ulation and downmodulation of the linking intermedi-ate concentration in the range of feasible values, and measurement of this concentration and the correspond-ing values of the rates. ... corresponding modules, the effect of changingsupply being much smaller. In addition, the change in one of the demand rates does not severely affect the flux of the competing branch. These properties ... changes in rate, what is another disadvantage for the independentregulation of the branches.Eliminating the feedback inhibition of AK1 and AK2 by Lys (G-III in Fig. 3) has minor effects on the control...
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Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
... concentration in a metabolic path-way as a function of the kinetic constants of the enzymesinvolved in that pathway [3]. Application of this methodpointed to the inhibition of the rate of synthesis of ... could affect the actual concentration of ATP and hence the rate of synthesis of inosine. It is here assumedthat the complex processes of syntheses and degradation of ATP in vivo (involving many ... nature and the concentration of the products formed in the course of the reaction were established by comparison with standards.Quantification was made from data obtained under linearconditions of...
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Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc
... ER protein (calnexin) and cytoskeleton protein (tubulin) in these cells as the internal controlproteins. The calnexin and tubulin levels were found tobe similar between these cells, confirming ... ⁄ ))]. These results indicatethat a functional deletion of Synoviolin causes a change in the intracellular trafficking of NCT.Effect of Synoviolin on the production of AbNCT is one of the essential ... directly interacting with the sub-strate proteins and helping to transfer ubiquitin tothem. Therefore, to determine whether NCT is the substrate of Synoviolin, we determined whether Syno-violin interacts...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
... within the range of normality (96 and 134%, respectively). Both parents were asymptomatic.Mutational screening The entire coding region, including exon–intronboundaries and $ 300 bp of the ... oneresidue following the cleavage site of FXI (P2¢ posi-tion, according to the convention of numbering posi-tion around the scissile bond), thus is part of the activation loop.One hundred haploid ... buried in the structure of FXIa, the introduction of a larger residue in this positionmost likely causes some degree of structural change;this is especially true in the case of the introduction of an...
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