Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... FEBSMINIREVIEW LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles Zhenyu YueDepartment of Neurology and Neuroscience, Mount Sinai School of Medicine, ... and LRRK2 homo-logs in slime mold, nematode worms and fruit flies. It also discusses theresults obtained from available mouse models of LRRK2 that begin toprovide information for understanding ... cytoskeleton proteins are knownas frequent ‘contaminants’ in the process of searchingbinding proteins, the in vivo evidence for the relation-ship between ROCO proteins and cytoskeletons in D. discoideum...
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Tài liệu Báo cáo khoa học: "Accumulation of Lexical Sets: Acquisition of Dictionary Resources and Production of New Lexical Sets" pdf
... source, human work in grammar writing and machine work in parsing can be reduced significantly. (2) Obtaining the result immediately without parsing. In some simple cases, using several replacement ... we will examine several common categories of production, point out basic operations often used in them, and finally, establish and implement a formalism for specifying and doing production. ... information and stripping unnecessary one. In many cases, much of the typographic information in the source text is not needed for the parsing phase, and can be purged straightforwardly in an adequate...
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Báo cáo khoa học: "A Rose is a Roos is a Ruusu: Querying Translations for Web Image Search" pdf
... to coil and none tothe jumping sense. Simple modifications to querydo not always work. Searching for spring waterresults in many images of bottles of spring water and searching for spring jump ... Word + Random (SW+R): Querying withthree pairs of source word and a random transla-tion. This is another natural way to extend thebaseline for the intended sense. (4) Random (R):Querying with ... select fifty English queries fromPANDICTIONARY and look up all senses contain-ing these in PANDICTIONARY, resulting in a totalof 134 senses. These queries include short wordsequences (e.g.,...
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Báo cáo khoa học: "USING AN ONLINE DICTIONARY TO FIND RHYMING WORDS AND PRONUNCIATIONS FOR UNKNOWN WORDS " doc
... techniques for segmenting and matching word spellings, and for mapping spelling to sound in known words. As in the case of rhyme, the computer model will be an important tool for improving our understanding ... uridine uriel urim and thumm urinal urinalysis urinary urinate urination urine urinogenital urinometer urinometric detergency surgeoncy insurgency convergency emergency indeterminacy ... outstanding questions related to the Matching and Combining steps. If matches cannot be found for initial and final substrings that overlap (as in the example) or at least abut, then information...
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Báo cáo khoa học: "Phrase-based Statistical Language Generation using Graphical Models and Active Learning" potx
... riverside inform(area)area inform(area) area informthat inform inform EMPTYserves inform(food) food informFrench inform(food(French)) French inform(food)food inform(food) food inform</s> ... Chinese restaurant near Cineworld in the centre of townCharlie Chan Chinese restaurant Cineworld centrename food type near near area areainform inform inform inform inform inform inform informt ... STARTThe Rice Boat inform(name(X)) X inform(name)is a inform inform EMPTYrestaurant inform(type(restaurant)) restaurant inform(type) in the inform(area) area informriverside inform(area(riverside))...
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Báo cáo khoa học: "Parsing with Treebank Grammars: Empirical Bounds, Theoretical Models, and the Structure of the Penn Treebank" ppt
... is of-ten done in parsing work (Collins, 1997, etc.). For 1Effectively “testing on the training set” would be invalidif we wished to present performanceresultssuchas precision and recall, but ... capture the varyingmagnitudes and exponents seen for different grammarencodings and tree transformations. Since thetermof comes directly from the number of start,split, and end points for traversals, ... edges and traversals of using top-down and bottom-up strategies.There are some extremely minimal savings in traver-sals due to top-down filtering effects, but there is a cor-responding penalty in...
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Báo cáo khoa học: Protein tyrosine phosphatases: functional inferences from mouse models and human diseases pot
... KIM-containing PTPs). In addition, specific isoforms withinsubtype families may contain additional protein domains and ⁄ or targeting sequences (e.g. the ER anchoring tail in PTP1B and the nuclearlocalization ... thandephosphorylation. Elegant work in cell models pro-vided an intriguing two-way mode of action in which a‘substrate-binding’ PTP combines phosphorylation-dependent and -independent protein interactions toregulate ... theimportant and diverse roles of protein tyrosine phosphatases in cellular sig-nalling pathways, development and disease. Here, we provide an overviewof those findings from mice and men, and indicate...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc
... but in concert with anumber of conserved domains, including a GTPasedomain. Multidomain proteins that encode functionalkinase domains often utilize intrinsic protein kinaseactivity distinct ... mechanisms for LRRK2- mediated cell death and kinase activation are proposed. As apromising target for neuroprotection strategies in PD, in vitro and in vivo models that accurately demonstrate LRRK2 s ... recognizablesubstructures within the kinase domains, with theexpectation that similar kinases may be involved in similar roles in cells. LRRK1 and LRRK2 are awk-wardly nestled within the tyrosine-kinase-like...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt
... complex proteins (ROC), C-ter-minal of ROC (COR), mitogen-activated proteinkinase kinase kinase and WD40 domains. The presenceof the four protein–protein interaction domains(ARM, ANK, LRR and WD40) ... WD40domain. Because WD40 domain is involved in mediat-ing protein–protein interactions, the LRRK2 G2385Rvariant may impact on interactions with substrates and ⁄ or regulatory proteins. Preliminary ... Genomic and protein structures of LRRK2. LRRK2 has 2527 amino acids and contains ARM, ANK, LRR, ROC, COR, MAP-KKK and WD40 domains. Proven pathogenic mutations are shown in red. Potentiallypathogenic...
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Tài liệu Báo cáo khoa học: Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker’s yeast doc
... proteins,PFK2, TDH3, GPM1 and -3, ENO2, PDC5 and ADH6 showed interaction with the yeast E3 ubiquitinligase RSP5 in a binding assay using protein chips [44]. For PFK, GPM, PDC and ADH this is in ... ubiquitin-activating enzyme (E1),ubiquitin-conjugating enzyme (E2) and ubiquitin pro-tein ligase (E3). E3 ubiquitin ligase binds directly tothe substrate proteins and thereby regulates the speci-ficity ... S1. C-flux in mmolÆCÆmin)1ÆgÆprotein)1duringfermentative capacity assay in samples from the nitro-gen-starvation experiments.Table S2. C-flux in mmolÆCÆmin)1ÆgÆprotein)1duringfermentative...
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