Báo cáo khoa học: Amyloid structure – one but not the same: the many levels of fibrillar polymorphism potx

Báo cáo khoa học: Amyloid structure – one but not the same: the many levels of fibrillar polymorphism potx

Báo cáo khoa học: Amyloid structure – one but not the same: the many levels of fibrillar polymorphism potx

... 4601 MINIREVIEW Amyloid structure – one but not the same: the many levels of fibrillar polymorphism Jesper S. Pedersen 1 , Christian B. Andersen 2,3 and Daniel E. Otzen 4 1 Department of Biochemistry, Molecular ... release from the cells, these amyloid structures would gradu- ally dissociate into active monomers in the blood- stream [17], which would imp...
Ngày tải lên : 23/03/2014, 03:20
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Báo cáo khoa học: "Re-Ranking Models For Spoken Language Understanding Marco Dinarelli University of Trento Italy" potx

Báo cáo khoa học: "Re-Ranking Models For Spoken Language Understanding Marco Dinarelli University of Trento Italy" potx

... annotation, in terms of the edit distance from the manual annotation, among the 10-best hypotheses of the FST model; (C) as above but s i is selected among the 100- best hypotheses. The pairs are also ... we noticed that many times the hypothesis ranked first by the SCLM is not the closest to the correct concept sequence, i.e. its er- ror rate using the Levensht...
Ngày tải lên : 08/03/2014, 21:20
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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt

Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt

... variations in the level of endogenous Ruk L, suggesting a long half-life for the protein (Fig. 4C). Furthermore, we examined the effect of selected inhibitors of protein degradation on the level of endogenous ... retains only the C-terminal coiled-coil region. Although the precise role of this Ruk/CD2AP family is still unknown, they are involved in the control of apo...
Ngày tải lên : 17/03/2014, 23:20
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Báo cáo khoa học: A designed curved DNA segment that is a remarkable activator of eukaryotic transcription potx

Báo cáo khoa học: A designed curved DNA segment that is a remarkable activator of eukaryotic transcription potx

... the tk promoter, although the extent of activation differed among these segments. For the seg- ments from T4 to T32, the extent of transcriptional acti- vation correlated with the length of the ... expression of transgenes, which is of importance in many areas of the biological sciences. Moreover, such technology could lead to the development of useful nonviral...
Ngày tải lên : 23/03/2014, 10:20
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Báo cáo khoa học: Crystal structure of human cystatin C stabilized against amyloid formation pdf

Báo cáo khoa học: Crystal structure of human cystatin C stabilized against amyloid formation pdf

... and B) in the asym- metric unit display the canonical cystatin fold, (N)–b 1– a–b2–L1–b3–AS–b4–L2–b 5–( C), with a five-stranded antiparallel b-sheet gripped around a long a-helix (Fig. 1). The AS is ... the presence of this extra bridge does not perturb the conformation of the main chain in the region of these point mutations. This is possible because the side cha...
Ngày tải lên : 22/03/2014, 21:20
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Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt

Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt

... potential (E°) of the substrate must be low enough, as the rate of the reaction has been shown to depend on the dif- ference between the redox potentials of the enzyme and the substrate (DE °) [2 8–3 1]. This ... attached to the T2 copper, as observed in the crystal structure of MaL. The unique fea- ture of TaLcc1 and MaL as compared with other laccases struc...
Ngày tải lên : 14/02/2014, 18:20
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Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

... and amide backbone groups. The one exception to this is the location of the amide group of Lys204 at P3, where there is a break in the main-chain density at the 2.8r map level. The corresponding ... primarily occurs by the formation of a hydrogen bond between the side-chain hydroxyl group of Tyr205 and the importin-a main chain at the C-terminus of the ARM1 H...
Ngày tải lên : 14/02/2014, 19:20
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Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

... [26]. These findings lead to the hypothesis that Fe-bound ApeSOD mimics the product-inhibited form and the shift of Tyr39 sup- presses the release of the peroxide product. This may be one of the ... the ter- tiary structure of ApeSOD has not been elucidated. In the present study, for the first time, we describe the crystal structure of ApeSOD. In particular...
Ngày tải lên : 14/02/2014, 22:20
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Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc

Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc

... well. The hydrogen bond between the backbone nitrogen atom of Asp291 and the 3- phosphate of the substrate is the only interaction with the protein backbone; all other contacts are formed using the ... identified. These are not part of the predicted binding mode of phytate to PhyK. Out of the water molecules included in the structure none is bound in the cat...
Ngày tải lên : 16/02/2014, 09:20
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Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

... of intrinsically dynamic behav- ior. These regions correspond to D11–E14, A46–R51, G53–C57, K83–G89, S101–A104, D117–N119 and G122–F125. Description of hirsutellin A structure The structure of ... transphosphorylation, which implies the A B Fig. 3. Stereo diagram of the active center of HtA. (A) Superposition of the active-site residues of the 20 conformers of t...
Ngày tải lên : 18/02/2014, 08:20
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