... Authors Journal compilation ª 2010 FEBS
The effect of zinc oxide nanoparticles on the structure of
the periplasmic domain of the Vibrio cholerae ToxR
protein
Tanaya Chatterjee
1
, Soumyananda ... work we report
the unfolding behavior of the periplasmic domain of the ToxR protein
(ToxRp) of Vibrio cholerae on zinc oxide (ZnO)...
... whether the expression of the RAMY gene is
induced by GA, and the possible relationship between the
expression of the RAMY gene and the Amy2 gene, we
performed a Northern blot hybridization e ... binding domain is present in the protein. This
conclusion is supported by the observations that the RAMY
Fig. 5. DNA binding is mediated by the zinc finger domain. (A) SD...
... regulation of
the three thyroid cell lines
We investigated the effects of XCT790, a specific
inverse agonist of ERRa. As controls of the inhibitory
effect of XCT790 on ERRa, we used the expression of
ERRa-validated ... vehicle. On the sixth day, the
cells were transfected with control or PRC
siRNA. (A) Oxygen consumption defined in
the basal condition (basal resp...
... regions of
gp41 [12]. During 100 days of serial passaging, HIV-1
strain BaL developed three cationic mutations in the
presence of sublethal concentrations of RC-101 [14]. Of
the three mutations, ... thus the
dependence of viral replication on the presence of
RC-101 is not surprising. The cationic mutations and
loss of glycosylated residues suggest an attempt by th...
... not
obligatory, to the atherogenic process. The important
corollary is that inhibition of such oxidation should
reduce the progression of atherosclerosis, independent
of reduction of other factors, ... alteration
in endothelial function, are considered among the early
events in the pathogenesis of atherosclerosis [43]. The
alteration of oxidant ⁄ antioxidant balance ma...
... observed on
mutating the amino acids involved in covalent flaviny-
lation. As mentioned before, removal of one of the
covalent bonds affects the redox potential. However,
on the basis of changes in the ... compari-
son of structure of the flavoprotein harboring
covalently bound FAD [39] with the structures of the
flavoprotein with noncovalently bound FAD or the...
... enhance Sp1 activity in these
conditions. This effect was no longer observed at
higher concentrations. The protein level of Sp1 was
checked in the different conditions: the results showed
that ... result of the loss of the
molecule during the extraction procedure: indeed, only
the nuclear proteins are recovered and the DNA is dis-
carded. By contrast, when echinomyci...
... scavengers used that only the
generation of
1
O
2
is responsible for the photooxidation
effects. The role of active oxygen scavengers in the
protection of the structure and function of the photo-
systems ... The main site of PSI photo-
inhibition under aerobic conditions was then shown
to be the inactivation of iron–sulfur centers [11],
whereas anaerobic photoinh...
... native PE.
Functionally, domain I of PE is the receptor-binding
domain, and is the major component of the B subunit.
Cancer therapy based on Pseudomonas exotoxin A J. E. Weldon and I. Pastan
4684 ... dependent on the
degradation of Mcl-1 and release of Bak [123]. The
anti-apoptotic protein Mcl-1 is rapidly turned over in
the cell, and inhibition of its synthesis...
... 3631
acids of the loop, Lys197 and Arg199 are highly con-
served, whereas the remaining 10 amino acids are only
moderately conserved. Crystallization of the enzyme in
the presence of the transition state ... [19–21]. The conformation of the flag
region, of which the flexible loop is a part, varies con-
siderably; the loop is either completely unresolved or
in a very...