... Therapeutics. Journal compilation ª 2010 FEBS
The pharmacological chaperone isofagomine increases
the activity of the Gaucher disease L444P mutant form
of b-glucosidase
Richie Khanna
1
, Elfrida R. ... wild-type human GCase activity in vitro [25].
The ability of IFG to cross the blood–brain barrier
and to increase the activity of L444P GCase enc...
... human
cells may affect the metabolism of the target cells in
more ways than just the therapeutic purpose of the
introduced gene. The normal function of nucleoside
kinases is to provide the cells with ... shown).
In order to test the enzymatic activity of the
Dm-dNK–GFP fusion protein and the level of nucleo-
side kinase activity in the cells, we determined t...
... to the discovered themes. Finally, the
V-matrix relates the original sentences to each of the
themes. The point of the SVD analysis is to discover
these themes based on co-variance between the ... differ-
ent assumption about the nature of the reading con-
text. Instead of taking the anchor text as an indicator
of the user’s information need, it assumes that t...
... understanding of system capa-
bilities. Of the remaining 66% of inputs (2166)
which were within the functionality of the system,
68% were in grammar. On the within functionality
portion of the data, the ... sets of scenarios and then freely interacting
with each system. For counterbalancing purposes,
half of the subjects used the tablet and then the re-
mo...
... 1.6808 0.6612
Y= the first right brother of the current node 0.4730 1.1525 0.7502
Y= the first left brother of the current node 0.5832 2.1511 1.2186
Y= the second right brother of the current node ... 0.5044 0.2525
Y= the second left brother of the current node 0.0949 0.6171 0.2697
Y= the first right brother of the parent 0.1068 0.3717 0.2133
Y= the first left...
... if the actions of the
CHH neuropeptides on repression of ecdysteroid synthesis
by the Y-organ (YO) are considered.
The most widely accepted paradigm of moult control
in crustaceans concerns the ... levels in the XO, and peptide levels in the SG
during these significant stages of the moult cycle, as these are
of fundamental importance with regard to the currently
acc...
... independently of
each other (one on the basis of the possible Eng-
lish questions about the subject-domain, the other
on the basis of the structure of the data base
about it) there must be ... items of English. The prim-
itives of the lowest semantic level are the prim-
itives of the data base (names of files, attributes,
data-items). The formal...
... effect (Fig. 4C). In the case
of L-ficolin, the interaction with CD91 was abolished
in the presence of EDTA, but the presence or absence
of Ca
2+
ions in the buffer had no effect on the interac-
tion ... Like
MBL and the ficolins they are pattern-recognition
molecules but do not share the property of binding the
MASPs and therefore do not activate the complement
casc...
... PARP-1-dependent derangement
of the integrity of the neurovascular unit is caused by
the enzyme’s ability to prompt an increase of blood–
brain barrier (BBB) permeability, the release of pro-
inflammatory ... occlusion
[41]. The key role of PARP-1 hyperactivation in endo-
thelial dysfunction in experimental models of diabetes
underscores the pathogenetic relevance of...
... analysis of
initial rate data in the absence of inhibitors, we used the
specific equation in Scheme 1. The effect of two ligands on
the activity of the wild-type DmAChE was evaluated by the
equation ... codes 1DX4 and 1QO9). One of
these conformations results in the formation of a chan-
nel approximately 5 A
˚
in diameter, connecting the
gorge to the bulk solven...