Báo cáo khoa học: Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo ppt
... displays high-affinity for the von Willebrand
factor binding site (RGQOGVMGF) in collagen and inhibits
carotid thrombus formation in vivo
Eric Calvo
1,
*, Fuyuki Tokumasu
2
, Daniella M. Mizurini
3
, ... was
detectable for collagen (lower right panel).
Aegyptin binds with high affinity to the vWF
binding site in collagen, independently of
h...
... peptide termini. The binding of PDZ domains is
dominated by the residues at the P
0
and P
)2
position within these C-ter-
minal targets, but other residues are also important in determining specific-
ity. ... role and even
may be a decisive factor in discriminating between low-
and high-affinity binding [17,18]. Residues further
upstream from the C-terminus are also de...
... to the control of each assay. Reactions were
incubated for 30 min at 25 and 4 °C, and then at 10 min
at 95 °C. Anthrone 0.2% in 95% H
2
SO
4
was added, and
the samples were incubated for 8 min ... concerning sucrose cycling, we
performed in silico experiments, using the validated
mathematical model in terms of predictive metabolic
engineering [18]. Replacing V
max
values...
... signalling pathways dur-
ing invasion in order to prevent uptake and killing. In
addition to actin, other host cell proteins have been
shown to bind to the virulence factor YpkA, including
OTUB1 ... that the ability of
YpkA to bind GTPases may be critical for the
OTUB1-mediated increased Yersinia uptake. We there-
fore tested whether YpkA and RhoA interact in vitro
and w...
... binding sites apparently are
not detected by MII argues against a role for a3inthe
formation of native MII binding sites, but may reflect the
scarcity of these sites in the investigated brain tissues ... nonequivalent binding sites within the
same receptor, together with the dominant inhibitory effect
obtained by binding of only one antagonist molecule,
represents a parti...
... the
transferrin receptor reveals overlapping HFE
and transferrin binding sites. J Mol Biol 313, 385–
397.
22 Lebron JA & Bjorkman PJ (1999) The transferrin
receptor binding site on HFE, the ... was func-
tionally deficient in b2-microglobulin interactions and incapable of
regulating transferrin binding, once again, reminiscent of the HFE-C282Y
variant. Single and dou...
... G to be
the set of pairs in the gold standard such that the
people involved in the pair in T communicate with
each other. These are precisely the dominance rela-
tions in the gold standard which ... dominance pair; “Inter” means that one element
of the pair is from the core and the other is not; a negative
error reduction indicates an increase in error
in a dom...
... 9.1 points yesterday morning"
Figure 3: the transformed form of the path with dash line for the second pass processing
2.4 The statistical parameter
training
In this work, the training and ... summarizes the average
performance on both baseNP tagging and POS
tagging, each section of the whole Penn
Treebank was used as the testing data and the
other 24 sections...
... parse the rest of the string
working outwards to the left and right, adding words
to each end of the 'island' formed. Indeed, any number
of islands can be built, the parser merging the ... BUILT ISLANDS
In the HWIM system, to join together two adjacent
islands to make one island covering them both, the
smaller island was broken up and the words from it...
... building blocks, resulting in the formation of
functional devices. Even the simplest living organism
contains functional complex elements such as motors,
pumps, and cables, all functioning at the ... radiation
Photoresist removal
Etching
DNA
Recognition
sequences
DNA -binding
proteins
Metallization
Protein removal
Fig. 3. Use of DNA -binding proteins for ‘molecular lithography...