... proteinase with a limited distribu-tion in certain cell types, including gastric epithelial cells [4], but is mainly present in cells of the immuneKeywordsantigen-presenting cells; cathepsin ... processing MHC II-associated invariantchain [24] in antigen processing and presentation[25,26]. CatE is also reported to be involved in antigenprocessing by B cells [27,28] microglia [29] and ... inhibitor of CatE, the Ascaris pepsininhibitor, which inhibits pepsins and CatE [33], butdoes not affect other types of aspartic proteinasesincluding CatD [31,34]. This inhibitor was originallyisolated...