Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf

... tightbinding afﬁnity was demonstrated towards lauric acid, resulting in the synthesis of mainly x-1 hydroxylatedlauric acid, suggesting a role in the lipid oxidative metabolism. Interestingly, the ... occurring in the soil. Furthermore, branched chain fatty acids make up80% of the fatty acid content of the Bacillus sp. mem-branes and when the hydroxylation of these substrateswas studied in ... proﬁles of bothstrains were quite different, suggesting the involve-ment of CYP102B1 in lipid biochemical pathways.I. N. A. Van Bogaert et al. The role of P450 in microbial fatty acid metabolism FEBS...

Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding afﬁnity pptx

... antigen in itself [7,20]. Atleast for these antibodies, the role of the VLdomainmight be to increase the affinity by supporting the VHdomain. The phenomenon may also be observed in the chain ... Although the Fv was designed based on HyHEL-10, it is not clearwhether or not H39 is dominantly tuning the VH⁄ VLinteraction of other Fvs, including HyHEL-10. In addition, the effect of the H39 ... clarify the effect of the interface mutations on the antigen-binding affinity. To investigate systematically thisunsought relationship between the antigen-bindingaffinity of Fv and the VH⁄ VLinteraction...

Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt

... example, in the case of questionQ209: “Who invented the paper clip ?”, the expected answer type is PERSON and so is the subject of the verb invented , lexicalized as the nominalization inventor. ... hypernyms in the answer se-mantic form.Step 3: The assessment of the similarities of dependencies. In the third step, two classes of similar dependencies are considered, generatinguniﬁcations of the ... example, in the case of TREC -9 question Q243: “Where did the ukulele originate ?”, the expected answer type isLOCATION. In the paragraph the ukulele intro-duced from Portugal into the Hawaiian...

Báo cáo khoa học: The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism pdf

... selective inhibitor of Glc6P hydrolysis [31],for evaluating the role of Glc6P, we determined the effect of different inhibitor concentrations on the Glc6P content and the rate of glycogen synthesis in hepatocytes ... that the increase of Glc6P in the presence of S4048 was caused by the inhibition of Glc6P hydro-lysis in the absence of detectable changes in glucosephosphorylation.S4048 causes inactivation of ... control of glycolysis and glycogen synthesis by glucokinase overexpres-sion. The validity of S4048 for testing the role of Glc6P was supported byits lack of effect on glucokinase binding and...

Báo cáo khóa học: The role of N-linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis pdf

... NuijensPharming, Archimedesweg, Leiden, the NetherlandsLactoferrin (LF) is an iron-binding glycoprotein of the innate host defence system. To elucidate the role of N-linkedglycosylation in protection of ... such as the pancreaticenzyme trypsin has been suggested [19,20]. The experiments described herein further elucidate the role of N-linked glycosylation in the protection of lactofer-rin against ... lactoferrin where the protein has to survive the harsh environment of the gastro-intestinal tract. Thus, on the basis of this study, rhLF maybe preferred over bLF in oral applications of lactoferrins...

Báo cáo khoa học: The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein ppt

... indicating that the effect of APMA on ACE sheddingwas not as a result of over-expression of the protein.Together these data conﬁrm that APMA induces the shedding of ACE but not the shedding of ... bothADAM10 and TACE are involved in the shedding of APP,neither ADAM is involved in the shedding of ACE.Furthermore we show that APMA can distinguish between the shedding of ACE and APP.Materials ... for the central role of ADAM10 and conﬁrming thatTACE has a minor role in the a-secretase cleavage of APP in human cells.During the course of the present study it was reportedusing an RNA interference...

Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

... through the exchange between subunits of either their N-ter-minal, or their C-terminal ends [33–35]. We foundthat the behavior with the model membrane of the dimer in which the C-terminal ends ... ‘r’) and variation of the inclination (inclination angle ‘i’) withrespect to the plane of the membrane (parallel to the xy plane).Cter and Nter are the C-terminal and N-terminal structural regions,respectively, ... electrostatic ﬁeld of differentFig. 5. Plot of the EIE values as function of rotation (r) and inclination (i) angles of RNases. The hatched axis at the bottom and right of the plots show schemes of some...

Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx

... undergoes fusion with the membrane of intra-endosomal vesicles contained within MVBs,thereby releasing the nucleocapsid into the lumen of these vesi-cles. Then, the capsid uses these intra-endosomal ... milddevelopmental delay. The protein defective in this disorder is alsoa NHEJ protein. The distinct clinical features of the patients willbe discussed in the context of the protein function.3.4 Diabetes, ... Mutations in the ERCC1 gene induce a distinct set of accelerated ageing features,with a rate of onset depending on the severity of the mutation. The correlation between repair defect severity and clinical...

Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx

... likely that the N-terminal domain is involved in protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspeciesinteractions are incompatible.From ... as a nother identiﬁcation of the complex at the position o f the histochemical stain in the left panel. Antisera against the SDHC subunit of complex IIand against the Rieske protein of complex ... and the effect of the absence of intact complex I, but the results are toopreliminary in this regard.Heterologous expression of the ESSS-HA subunit The localization of the ESSS subunit in the...

Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafﬁcking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efﬁcient GABA-uptake activity of the GABA transporter pptx

... N-linked oligosaccharide side-chainsare important for the GABA transport activity.1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into the role of the terminal ... results in reduction of the stability of GAT1 In order to study the in uence of the N-glycosylationand N-linked oligosaccharides on protein stability, the intracellular decay time of the GAT1, ... slowed kinetics of the transport cycle. This indicates thatN-glycans, in particular their terminal trimming, are important for the GABA-uptake activity of GAT1. They play a regulatory role in the...

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