Báo cáo khoa học: Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA docx
Báo cáo khoa học: Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA docx
... allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA Kenneth L. Seldeen, Brian J. Deegan, Vikas Bhat, David C. Mikles, Caleb B. McDonald andAmjad ... propagation of informationfrom one monomer to another, which is often the hall-mark of binding of dimeric transcription factors to palindromic DNA sequences [1–5]. Although it addscomplexity to the ... that an intricate network of energetically-coupled residues within the basic regions of the Jun-Fos heterodimeric transcription factor accounts for its allosteric binding to DNA. Remarkably, energetic...
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Tài liệu Báo cáo khoa học: "ModelTalker Voice Recorder – An Interface System for Recording a Corpus of Speech for Synthesis" ppt
... within an acceptable range. This feedback mechan-ism also helps to eliminate cases in which the sys-tem is unable to accurately track the pitch of an utterance. In these cases, the utterance ... recorded, the user rece-ives feedback on the overall quality of the utter-ance. Specifically, the user receives feedback on the pitch, the overall amplitude, and the pronuncia-tion of the recording. ... voice. To reduce the incidence of alternate pronunciation, the user is prompted with both a text and an audito-ry version of the utterance. 1.2.3 Recording Feedback Once an utterance has been...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
... complexes [29]. On the other hand,kcat⁄ Kmis an apparent second-order rate constant thatrefers to the properties and the reaction of the freeenzyme and free substrate [29]. We have therefore esti-mated ... than those in the absence of sugars, i.e. Kmis decreased. On the otherhand, this change in conformation results in a decreasein kcat, the turnover number of the enzyme in the pres-ence of ... deriva-tives have little or no effect on the solvation properties of the substrate and the enzyme active sites or on theirthermodynamic activities. Another explanation forthese observations comes from...
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Báo cáo khoa học: "COMMON TOPICS AND COHERENT SITUATIONS: INTERPRETING ELLIPSIS IN THE CONTEXT OF DISCOURSE INFERENCE" ppt
... VP-ellipsis patterns with other types of anaphora, for instance it can be cataphoric and can locate antecedents from clauses other than the most immediate one. 52 one of two ways. The syntactic VP ... terms of two features: (1) whether the form leaves behind an empty constituent in the syntax, and (2) whether the form is anaphoric in the semantics. In subsequent sections, we show how the ... elliptical and event referential forms according to two features: (1) whether the expression leaves behind an empty constituent in the syntax, and (2) whether the expression is anaphoric in the semantics....
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Báo cáo khoa học: X-ray crystallography, CD and kinetic studies revealed the essence of the abnormal behaviors of the cytochrome b5 Phe35fiTyr mutant pdf
... Tyr35 and the hemegroup in the Phe35fiTyr mutant. The overall structure of the Phe35fiTyr mutant is basically the same as that of the wild-type Tb5. The r.m.s. deviation for a total of 82 Caatoms ... extends into the solventand does not form any hydrogen bond with the proteinatoms. The former propionate displays the conservedconformation in the structures of the Phe35fiTyr mutantand of the wild-type ... [35,36,40,41]. The apo-cyt b5and apo-Mb have no absorption in the Soret bandregion because of the lack of the heme prosthetic group. For the holo-cyt b5and holo-Mb, the CD spectra of the Soretband...
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Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
... general mode of CIII activity, or does it apply only for CII? Weexamined the mode of the inhibitory action of CIII onproteolysis of the heat shock sigma factor r32, anothersubstrate of HflB. Like ... min in the presence of His6–CIII or CIIIC (up to 200 lM) areshown in the upper panels. Numbers on the top of each lane indi-cate the concentration of His6-CIII or CIIIC (in lM). Lane C indicates the ... 11% SDS ⁄ PAGE, in the presence orabsence of 5 mM ATP. Numbers on the top of each lane indicate the time of digestion in min. (Lower) Densitometric scan showing the amount of r32-C-his (1.2...
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Báo cáo khóa học: CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes doc
... Upon densito-metric analysis of the immunoblots it became clear that the amount of CD38 expressed on the plasma membrane and the total amount of CD38 expressed by the varioustransfectants correlated ... NP-40 (lane 1), Triton X-100 (lanes 2 and 3), digitonin (lanes 4and 5), Chaps (lanes 6 and 7) or deoxy-BigChap (lanes 8 and 9).Lysates were immunoprecipitated with antibody to CD38 (NIM-R5)and ... cells; dark linehistograms, Ba/F3 transfectants. The mean fluorescence intensity of the cells from each of the transfectants is listed above the histogram. (D) Post-nuclear supernatants were prepared...
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Báo cáo khoa học: "A Feedback-Augmented Method for Detecting Errors in the Writing of Learners of English" docx
... types of : , , and that denote the contexts consisting of the noun phrase that the tar-get noun heads, words to the left of the nounphrase, and words to its right, respectively. Then the template ... confidence of ratiois measured by the reciprocal of variance of the ratio (Tanaka, 1977). Variance is calculated by(6)where denotes the number of samples used forcalculating the ratio. Therefore, ... (the above two methods and their sevenvariants). The words in brackets denote the cor-pora used to learn decision lists; the symbol “+FB”means that the feedback corpus was simply added to the...
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Báo cáo khoa học: b3-Adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat pptx
... h)before the beginning of each experiment. They were thendivided into three groups, one maintained at 24 °Candtheother two exposed to cold (6 °C) for either two or 10 days. The fat pads along the ... in the WATdepot and it was therefore not possible to assess the number of these cells and to compare it to that in WT mouse WAT.Genital pads of b3KO mice were 1.5-fold heavier thanthose of ... [26]and 10 lg of homogenate proteins were used to measure the cytochrome c oxidase activity by the method of Yonetaniand Ray [28].StatisticsData are presented as mean ± SE and were analyzed...
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Báo cáo khoa học: cGMP and glutathione-conjugate transport in human erythrocytes The roles of the multidrug resistance-associated proteins, MRP1, MRP4 and MRP5 pot
... transport in human erythrocytes and so the low affinitytransport of DNP-SG and the transport of cGMP may bemediated by one and the same transporter. The character-istics of transport indicate ... werecompared using an F-testontheratioofthevarianceassociated with the reduction in degrees of freedom to the variance of the fit with the smaller number of degrees of freedom [33],VR ¼ðSSE2À ... between cGMP and DNP-SG uptakeinto human erythrocyte membrane vesicles To explore the relations between cGMP and DNP-SGtransport, the ability of each to inhibit transport of the otherwas investigated....
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