... dowregulation of NMNAT1 expression does not affect the rate of axon degeneration in vitro.DiscussionThese data indicate that complete NMNAT1 geneinactivation is incompatible with the normal develop-ment ... Journal compilation ª 2011 FEBS 2679 Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration Laura Conforti1,2,3, Lucie Janeckova1, Diana Wagner2, ... develop-ment of embryos, as the extranuclear isoformsNMNAT2 and NMNAT3 cannot compensate forcomplete loss of NMNAT1. Nmnat1 + ⁄ )mice havereduced NMNAT1 expression and enzyme activity;however, they...