... The NetiPotisasoothingnasallavage.Asaltmixtureofappropriateconcentration and temperatureisprepared. The patientleansover the sink and applies the NetiPotto the uppernostril, the salinesolutionflowsthrough the nasal and sinuscavities and around the backwallof the septum and washes the oppositenasal and sinuscavitiesbeforeexiting the dependentnostril. ... terlevelrises and areservoirforms.Similarly,if the osteomeatalcomplexisblocked,abackupofmucusoccurs.Thiscanleadtoaconditionthatleadstoinfection.Bacterialivein the nose and sinuses;however,inaninfectiousstatesomesubset(s)ofbacteriahavereproducedoutofproportiontoothers.Thisbacterialovergrowthisoftenpresentinsinusitis–particularlyacutesinusitis.Anyprocessthatcausesmucosalinflammationinto the sensitiveareaof the osteomeatalcomplex(OMC)canocclude the othersinusesthatdrainintothiscrossroadzone.(16‐20)Blockageof the smallopeningsfromswelling(causedbyinfection,allergy, and othercauses)canalsoresultinsinusitis.Whenobstructionoccurs, the mucusisretainedin the sinuscavity.Thesestagnantsecretionsthicken and provideamediumforbacterialgrowth.Obstructionalsoimpairsaeration and gasexchangewithin the sinuscavity.Absorptionoftrappedoxygenleadstohypoxiaordecreasedoxygenlevelswithin the sinus,whichexacerbatessinusitis.Thesechangesleadtodamage and dysfunctionof the cilia and epithelium. The retainedsecretions and infectionleadtofurthertissueinflammation,whichinturnleadstofurtherblockage.Thesechanges120help the bodyfightsinusitis.(51‐52).However,onecriticismofthisuseof the macrolideantibioticsisthatthereisariskthatbacteriacouldbecomeresistanttotheseantibioticsiftheyareoverused,therebypotentiallycreatingadifficultproblemintreatinginfectionwithresistantbacteria.N.Steroids ... Steroidsareanti‐inflammatorymedicationswhichareusedin the treatmentofsinusitisinbothatopical(nasalspray) and systemic(pill)form.(19‐27)Becausetopicalsteroidsarequiteeffectiveforallergic and non‐allergicrhinitis,systemicsteroidsareusedlesscommonlythansteroidsprays.Steroidshelpprevent and decreaseswellingof the liningof the nose and sinuses.Theyalsohelptodecrease the sizeofpolyps and maypreventthemfromrecurringoncetheyhavebeenremoved.Steroidsworkbyseveralmechanisms,including the stabilizationoflysosomalmembranes,blockageofmigratoryinhibitoryfactor, and decreaseincapillarypermeability....