... al., 1990). 4. Biologically active molecules from animals affecting heart physiology Animal venoms are usually a complex mixture of polypeptides, enzymes and molecules which can cause cell ... consist of distension of the sarcoplasmic reticulum of myocytes, cytoplasmic vacuolization, swelling of mitochondria and myofibrillar disarray and loss (Ferrans et al., 1997). Symptoms of the ... sodium channels as primary targets of diverse lipid-soluble neurotoxins. Cellular Signalling, Vol. 15, No. 2, (Feb 2003), pp. 151-159, 0898-6568 Williams DL. Jr., Jones KL., Colton CD. &...