... Alimentari, Farmaceutiche e Farmacologiche, University of Piemonte Orientale ‘A. Avogadro’,Novara, Italy2 Department of Molecular Pathology and Innovative Therapies, Section of Biochemistry, Universita`Politecnica ... the citric acid cycle, or conversion into NADthrough QA synthesis. Both PA and QA are key players in a number of physiological and pathological conditions, mainly affecting the central ner-vous ... controlled,modulation of ACMSD activity appears to be a promising prospect for thetreatment of neurological disorders, including cerebral malaria. Here wereport the 2.0 A˚resolution crystal structure of human...