... gene containing a trinucleotide repeatthat is expanded and unstable on Huntington’s diseasechromosomes. Cell 72, 971–983.6 Young AB (2003) Huntingtin in health and disease.J Clin Invest 111, ... HDtranslates into an expanded polyglutamine tract in theN-terminal region of the huntingtin protein. Repeatlength correlates with age of onset and accounts for50–70% of variance in onset [7]; however, ... effect against AD [119]. Intake of omega-3fatty acids from fish, vitamins E, B6, B12, and folate, and a moderate intake of red wine, are all associatedwith a reduced risk of developing sporadic...