Báo cáo Y học: Synthesis of phosphoenol pyruvate (PEP) analogues and evaluation as inhibitors of PEP-utilizing enzymes pot
Báo cáo Y học: Synthesis of phosphoenol pyruvate (PEP) analogues and evaluation as inhibitors of PEP-utilizing enzymes pot
... as inhibitors of the reactionbetweenADPandPEPcatalysedbypyruvatekinase.Pyruvic acid is one of the products of this reaction.Therefore, activity was measured by coupling the formation of pyruvate ... J. Biochem. 269) Ó FEBS 2002 Synthesis of phosphoenol pyruvate (PEP) analogues and evaluation as inhibitors of PEP-utilizing enzymes Luis Fernando Garcı´a-Alles and Bernhard ErniDepartement ... cell-wall biosynthesis (cata-lysed by UDP-GlcNAc enolpyruvyl transferase) and thebiosynthesis of aromatic amino acids (3-deoxy-D-arabino-heptulosonate-7-phosphate synthase and 5-enolpyruvyl-shikimate-3-phosphate...
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Báo cáo Y học: High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences doc
... High affinity binding between laminin and laminin binding protein of Leishmaniais stimulated by zinc and may involve lamininzinc-finger like sequencesKeya Bandyopadhyay, Sudipan Karmakar, ... Ghosh and Pijush K. DasMolecular Cell Biology Laboratory, Indian Institute of Chemical Biology, Jadavpur, Calcutta, IndiaIn the course of trying to understand the pathogenesis of leishmaniasis ... The assembly of BM is believed to involve theindependent polymerization of collagen type IV and laminin, as well as high affinity interactions betweenlaminin, enactin/nidogen, perlecan and collagen...
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Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf
... autophos-phorylation and kinase activity of PAK were stimulated bybinding to activated Rac/Cdc42, which thereby directlymodulates the enzyme activity [7–11]. However, Rho didnot show binding activity ... 95%neutrophil granulocytes.Measurements of reactive oxygen speciesSuperoxide generating activity was spectrophotometricallyassayed by monitoring SOD-inhibitable ferricytochrome creduction ... Rac, PAK and p67phoxproteins were not detected in the plasma membrane of dormant granulocytes in spite of the fact that they wereobserved abundantly in cytoplasm. Whereas reactiveoxygen species...
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Báo cáo Y học: Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17–21 for the oligomerization state and bioactivity of hCt ppt
... and in vivo hypocalcemic potencies were assessed.The novel analogues include cyclo17,21-[Asp17,D-Phe19,Lys21]hCt (2), cyclo17,21-[Asp17,Aib18,Lys21]hCt (3),cyclo17,21-[Asp17,D-Lys18,Lys21]hCt ... ffect of the inversement of ch irality of Phe19 onin vivo bioactivity of 1. In contrast, 6 had the same potency and maximum effe ct as hCt which suggested that inverse-ment of chirality of L ys18 ... assay, 3 and 4 were as potent as 1,whereas 2 completely lost the high potency of 1, s uggestingthat type I ( and II¢) b turn-promoting substituents are fullycompatible with in vivo bioactivity....
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Báo cáo Y học: Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle potx
... yeastcell cycle. They rapidly decrease w ith the entry of yeast cellsinto S phase and increase again during t he following G1phase with the synthesis of new Cdc6p.In contrast, the rapid S-phase-related ... (0–2 h afterthymidine-block) and in the middle of S phase (4–6 h), as well as at the e nd of mitosis and during the early G1 phase(12–14 h) of the next cycle (Fig. 2A).Cytoplasmic and chromatin ... G1 phase and the S phase of the cell cycle. Newly synthesized Cdc6passociates with chromatin. Pulse–chase e xperiments showthat chromatin-bound newly synthesized Cdc6p has a halflife of 2...
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Báo cáo Y học: Synthesis, characterization and application of two nucleoside triphosphate analogues, GTPcNH2 and GTPcF pdf
... investigated. The rate of hydrolysis of GTPcNH2bound to Ras protein lay betweenthe rates found for Ras-bound GTPcS and GppNHp, whileRas-catalysed hydrolysis of GTPcF was almost as fast as forGTP. The ... function,structure and mechanism, often demands use of nonhy-drolyzable or slowly hydrolyzable nucleotide analogues. These modifications become necessary when stabilization of a specific isoform of the protein ... Yount [33], and used to study its interaction with the GTP-binding site of adenylyl cyclase [34]. We synthesized this substance byTable 4. Intrinsic GTPase rate of wild-type H-Ras(1)167)Mg2+proteinat...
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Báo cáo Y học: Synthesis, conformational analysis and biological activity of cyclic analogs of the octadecaneuropeptide ODN Design of a potent endozepine antagonist pot
... thosepreviously observed with ODN and OP [12]. However, wefound that the potency of cyclo128OP was increased by afactor of three and its efficacy by a factor of 1.4 compared toits linear counterpart ... preloaded 4-hydroxymethyl-phenoxymethyl-copolystyrene-1%-divinylbenzene resin[Fmoc-Lys(Boc)-HMP], O-benzotriazol-1-yl-N,N,N0,N0-tetramethyluronium hexafluorophosphate (HBTU),1-hydroxybenzotriazole ... piperidine and N,N-diiso-propylethylamine (DIEA) were purchased from AppliedBiosystems (St Quentin en Yvelines, France). Preloaded poly(ethylene glycol)–polystyrene resin [Fmoc-Asp(PEG-PS)-OAl] was...
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Báo cáo y học: "Electronic patient record use during ward rounds: a qualitative study of interaction between medical staff"
... validation of hypotheses generated during video analysis about the interac-tion. Quantitative measures were not used as it was unlikelythey would provide external validity in this situation of complexsocial ... months after deployment of the system, and the effects of the introduction of the EPR on group interactionwere discussed. Patient privacy was ensured at all times byavoiding capture of images that ... consultant in this case loses his ability to guide thefocus of the group and, not surprisingly, the gaze of the medi-cal staff in the outer ring tends to wander.One year after deployment of the EPR,...
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Báo cáo y học: "980 nm diode lasers in oral and facial practice: current state of the science and art"
... suggestions of scientific literature on the advantages of the compactness, reliability, ease of use and affordability of the 980 nm Diode Lasers, we evaluated the efficacy and safety of one such Laser ... Immunology and Infectious Diseases, Unit of Dermatology, University of Bari, Italy Correspondence to: Dr. Andrea BALLINI, PhD., Department of Dental Sciences and Surgery, University of Bari, ... results for the use of the 980 nm diode laser in oral and facial sur-gery appears to be justified on the grounds of efficacy and safety of the device, and good degree of acceptance by the patients,...
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Báo cáo y học: " Laugh Yourself into a Healthier Person: A Cross Cultural Analysis of the Effects of Varying Levels of Laughter on Health"
... lifestyle. The total score was thirty-seven. Lifestyle Q1 to Lifestyle Q3 were equally weighted and represented 81% of the total value of the questions, whereas, Lifestyle Q4 and Lifestyle Q5 ... appropriately describe laughter-associated-asthma. The World Health Organization defined health as a “state of physical, mental and social well-being and not merely the absence of disease or bodily ... and Regulatory Operations). Moreover, post-secondary students were surveyed through an online survey website, Survey Monkey. The online survey (http://www.surveymonkey.com/s.aspx?sm =tTYWdl431H8mcvtwvQIwuw_3d_3d)...
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