Báo cáo khoa học: "PHRASE STRUCTURE TREES BEAR MORE FRUIT THAN YOU WOULD HAVE THOUGHT" ppt

... PHRASE STRUCTURE TREES BEAR MORE FRUIT THAN YOU WOULD HAVE THOUGHT* Aravind K. Joshi and Leon "S." Levy Department ... gremmmrs [e.g., i, 2, 3, 4]. We will present several results and ideas related to phrase structure trees which have significant relevance to computational lin- guistics. We %~_nT to accomplish ... related work, we have discovered that it is possible to characterize structural descriptions (for phrase sl-r~crure gz%m~mars) entirely in terms of trees without any labels, i.e., trees which capture...

Báo cáo khoa học: Crystal structure of a staphylokinase variant A model for reduced antigenicity pptx

... Biochem. 269) Ó FEBS 2002the ®rst to contain more than one SAK molecule in anasymmetric unit.The SAK(S41G) structure presented here is similar tothe monomer structure, SAKSTAR, previously reportedby ... ithDENZOandscaledwithSCALEPACK[25]. Structure determinationThe c rystal structure has been determined at 2.3-AÊresolu-tion using molecular replacement with a model from apreviously determined SAKSTAR structure (RCSB ... coworkers [30]. Comparing the twostructures, t here are 16 residues (residue S1±S16) missingfrom SAKSTAR, while the N-terminus in the SAK(S41G) structure was more structurally de®ned. Molecule...

Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt

... crystal structure of TaLcc1 does not have a chloride attached tothe T2 copper, as observed in the crystal structure of MaL. The unique fea-ture of TaLcc1 and MaL as compared with other laccases structures ... crystal structures of laccases from fungi andbacteria are available, but ascomycete types of fungal laccases (asco-lac-cases) have been rather unexplored, and to date only the crystal structure of ... laccase struc-tures were published in 2002, and crystal structures fromat least 10 different organisms have now been reported.Most of the structures are from sporophoral basidiomy-cota fungi:...

Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

... complex (observed structure factorsFpepo) with an apo structure of importin-a (70–529)(observed structure factors Fapoo). This structure is describedin ref. [42]. The structure factors ... translocation; however,in the crystal structure of soluble CLIC4, the putativeNLS adopts a helical conformation that would pre-clude binding to importin-a (refer to Fig . 2D). More recently, it has been ... hydrogen bondsformed by Tyr205 may suggest that a Tyr at P4 is more favourable than a Phe or other bulky residue, itis likely to have a similar energetic contribution topeptide binding as Val...

Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

... Becauseelectrostatic interactions in proteins are more domi-nant when the solvent polarity is lower, we hypo-thesized that ApeSOD would be more stable than TthSOD in an organic solvent.When we compared ... of ethanol in the solution destabilized bothApeSOD and TthSOD. However, the extent of thedestabilization was more signiﬁcant in TthSOD than inApeSOD (Fig. 4C). In other words, ApeSOD was more ... referredas to cambialistic SODs. In addition to the tertiarystructures of metal-speciﬁc SODs [4], crystal structuresof several cambialistic SODs have been reported,including those from Porphyromonas...

Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc

... crystal structures reportedhere, PhyK seems to have a preformed substrate-bind-ing site and to be less optimized for efﬁcient substratehydrolysis than AppA.Results and DiscussionOverall structure The ... with E. coli phytase AppAOverall, PhyK bears signiﬁcant structural similarity toother HAPs. A structure- based search with dali [17]revealed several similar structures. With rmsd values of2.3 ... domain of HAPs is evolutionarily more conserved than the a domain. For example, thephytase of Aspergillus fumigatus shows closer similarityto PhyK in the a ⁄ b domain than in the a domain [20].This...

Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

... HtA. With thisaim, we determined the structure of HtA by1H-NMRmethods, and the possible structure function relation-ships have been discussed. The solution structure issimilar to those reported ... structural requirements for activities unique to ribotoxins.Here, we have determined the structure of HtA by NMR methods. The structure consists of one a-helix, a helical turn and seven b-strands ... cycles of NOE assignment and structure calculation by cyana⁄ candid, a set of 20 structures thatsatisfy the experimental constraints was obtained. TheSolution structure of hirsutellin A A....

Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx

... membersdifferentially expressed in several organs and certaintumors. To date, more than 30 mammalian members ofthis group have been identified and have, according totheir sequence similarity, been grouped into ... Tyr60ghydroxyl group. As seen in the structure- basedsequence alignment (Fig. 3), the residues at position 41in the other TTSPs are significantly smaller and more hydrophobic than the Arg41 side chain in ... and refine-ment system for macromolecular structure determin-ation. J Appl Crystallogr 11, 268–272.27 Jones TA & Thirup S (1986) Using known substructuresin protein model-building and crystallography....

Tài liệu Báo cáo khoa học: Crystal structure of the BcZBP, a zinc-binding protein from Bacillus cereus doc

... proteinsof the family have been structurally characterized todate: TT1542 from Thermus thermophilus [7] andMshB from Mycobacterium tuberculosis [8,9], whosestructures have been determined at ... Quaternary Structure server(http://pqs.ebi.ac.uk/). These values indicate a signiﬁ-cant stabilization upon hexamerization. In agreementwith the crystal structure, gel ﬁltration experiments have ... supplementarymaterials supplied by the authors. Any queries (other than missing material) should be directed to the corres-ponding author for the article.Crystal structure of BcZBP from B. cereus V. E. Fadouloglou...

Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt

... thermsd of a structure is less than 1 A˚compared to the lowestenergy structure in that starting position, that was groupedtogether with the lowest energy structure forming a clusterof structure. ... Acomparison of the b-turn structure of cER with the similarregion in the crystal structure of rat and human CD2 wascarried out. In the rat CD2 crystal structure, the b-turn structure was exhibited ... addition to the primary structure of thepeptide.To conﬁrm our hypothesis that the b-turn structures areimportant for the inhibitory activities of the peptides, thestructures of the cyclic...

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