... examining the role of GIF in AD, linked to its initial discovery as a factordeficient in the AD brain. There remains no clear con-sensus on the role of GIF in the pathogenesis of AD,and therefore ... discovery of a brain-specific MT isoform, GIF, in 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularlywithin the injured or diseased brain. In the ... secretion in the brainTaken together, the regulation of GIF synthesis byreactive astrocytes, and its subsequent secretion undercertain conditions, could be intimately involved in regulating how the...