Báo cáo Y học: Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces docx
... and enhances binding of
tissue-type plasminogen activator to cancer cell surfaces
Jun Tsunezumi
1,2
, Kazuhiro Yamamoto
1
, Shouichi Higashi
1,2
and Kaoru Miyazaki
1,2
1 Division of Cell Biology, ... for matrilysin, and
investigated the biological consequence of annexin II
cleavage by matrilysin. Our results suggest that the
specific cleavage of annexin...
... agmatine [8,30], and clonidine
[16,30] binding to NOS-I, NOS -II, and trypsin. Remark-
ably, the affinity of N-amidino-2-hydroxypyrrolidine for
NOS-I, NOS -II, and trypsin is systematically higher than
that ... ·
10
)1
M
phosphate buffer) and 25.0 °C (Fig. 1). Values of
k
cat
and K
0
m
are independent of the enzyme assay.
Biosynthesis of
N
-amidino-2-hydroxypyrrolidine
N-...
... head of the table,
leaning in towards the paper and spreading his hands across
it. His body orientation towards the charts suggests them to
be the primary focus of the conversation and everyone ... bedside into a highly customizable interface.
The record includes parameters from ventilators, monitoring
devices, laboratory results, prescriptions, and medical and
nursing records....
... tract, hepatobiliary system, genitourinary
system, reproductive system, CNS and psychiatric
conditions, and then to specify the name of that con-
dition. If the participant failed to indicate ... University of
Toronto, being awarded an academic scholarship
from the University of Toronto. He was chosen for the
Research Opportunity Program, to pursue research in
the field...
... factors in a
long-term perspective are scarce. The results of the study suggest that life-style factors such as mental stress,
obesity and smoking among women are related to airway symptoms and ...
stress, obesity and smoking among women are related
to symptoms in the airway and also quality of life in a
long-term perspective.
Acknowledgements
This study was funded by gr...
... risk of
Helicobactor pylori infection and gastric atrophy
Yasuyuki Goto
1
, Takafumi Ando
2
, Kazuko Nishio
1
, Sayo Kawai
1
, Yoshiko Ishida
1
, Mariko Naito
1
, Hidemi
Goto
2
, Nobuyuki ... apparently H.
pylori-negative subjects were indeed truly negative or
they eventually led to loss of the infection due to sever
gastric atrophy. Because, in our study, gastric atrop...
... Department of Kinesiology, SooChow University, Taipei, Taiwan
2. Laboratory of Exercise Biochemistry, Taipei Physical Education College, Taipei, Taiwan
3. Department of Kinesiology, National ... 2006.09.10
The purpose of this study was to determine the association between the level of salivary dehydroepiandroster-
one sulfate (DHEA-S) and the magnitude of adaptation to ex...
... A 30-year-old woman presented with a 1-
year history of a palpable, asymptomatic right breast mass without axillary lymphadenopathy and family
history of breast carcinoma. Malignant phyllodes ... presented with a 1-year
history of a palpable, asymptomatic right breast mass.
There was no family history of breast carcinoma. No
axillary lymphadenopathy was identified.
Mammography...
...
Different factors and a variety of genes may
contribute to the chain of events that eventually lead to
lymphomagenesis. In an initial study to identify genes
differentially transcribed in HIV and SIV-associated ...
monkey lymphomas and monkey B-lymphocytes. Those
cDNAs whose hybridization signals were markedly
stronger with lymphoma cDNA than with cDNA of B-
lymphocyt...
... cloning of Aiolos and Helios [6–8], and of
Eos and Pegasus [9], revealed the existence of a family of
related factors. Ikaros, Aiolos and Helios are all abundantly
expressed in the haematopoietic system ... reporter
vector contained five copies of the Gal4 DNA -binding
domain upstream of the TK promoter in the vector pGL2-
TK (Promega).
Yeast two-hybrid and pull-down ass...