... role in the trafficking of growth factor/ receptor complexes through early endosomes. Stimulation of cells with epidermal growth factor (EGF) rapidly leads to phosphorylation of Hrs, raising the question ... Phosphorylation of Hrs downstream of the epidermal growth factor receptor Kristi G. Bache1, Camilla Raiborg1, Anja Mehlum1, Inger Helene Madshus2and Harald Stenmark11Department of ... 3–4), the phosphorylation was much weakerthan that detected at 37 °C, supporting the idea thatendocytosis of the receptor/ ligand complex is important for the phosphorylation of Hrs. Nevertheless,...