Báo cáo Y học: RING finger, B-box, and coiled-coil (RBCC) protein expression in branchial epithelial cells of Japanese eel, Anguilla japonica pot
Báo cáo Y học: RING finger, B-box, and coiled-coil (RBCC) protein expression in branchial epithelial cells of Japanese eel, Anguilla japonica pot
... (RING finger, B-box, and coiled-coil) protein was identified that belongs to the superfamily of zinc-bindingproteins and is specifically expressed in the gill of eel, Anguilla japonica. Euryhaline ... B-box, and coiled-coil (RBCC) proteins are agroup of zinc-binding proteins that belong to the RING finger family. They are so called because they have anN-terminal RING finger motif defined by one ... activity, suggesting an importantregulatory role of eRBCC in the remodeling of branchial cells. Keywords: freshwater adaptation; gill; RBCC protein; RING finger; ubiquitin ligase. RING finger, B-box,...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
... FEBS 3099chymotrypsinogen numbering is indicated in parenthe-ses) is the key contact point with TF [9–12]. A number of loss -of- function mutations were identified in an ala-nine scanning mutagenesis ... strongly in favour of the former, can be identified by gain -of- activity mutations. Site-directed mutagenesis at certainpositions in FVIIa has indeed resulted in moleculeswith increased intrinsic ... FVIIazymogenicity and elucidating the pathway of TF-induced allostery. In recent years, we have studied thesolution structures of various forms of FVII(a) usinghydrogen exchange mass spectrometry (HX-MS)....
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Báo cáo Y học: Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin a-sarcin potx
... ribotoxins.Keywords: Aspergillus protein; cytotoxin; protein –lipidinteraction; ribotoxin; a-sarcin.a-Sarcin is the best characterized member of a family of fungal cytotoxic ribosome-inactivating ... catalysis by a-sarcin [19,20],rendered proteins with no detectable activity against ApA[20]. Cleavage of ApA by a-sarcin is a low-specificityreaction requiring high amounts of protein and long incu-bation ... J.G.(1993) Kinetic study of the cytotoxic effect of a-sarcin, a ribosomeinactivating protein from A. giganteus, on tumor cell lines: protein biosynthesis inhibition and cell binding. Mol. Cell....
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Báo cáo y học: "Lifetime health effects and medical costs of integrated stroke services - a non-randomized controlled cluster-trial based life table approach"
... using original length of stay data and 2003nursing day prices. Subsequently, total individual costs of care during the first six months were computed byholding the original ratio between inpatient ... point representing a cost sav-ing of € 5,990 and a QALY gain of 0.51. The point esti-mate for the ICER is €11,685 saved per QALY gained;€14,211 and €7,745 saved per QALY gained for men and ... toincrease. In 20 years, the prevalence of stroke in theNetherlands will be more than 40% higher as a result of aging of the population, continuing unhealthy lifestylesamong elderly, and improved...
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Báo cáo y học: "2009 H1N1 Influenza and Experience in Three Critical Care Unit"
... critical care departments during winter of 2009 in Turkey. MATERIAL AND METHODS In response to an outbreak of influenza A virus infection in Mexico, Turkish Ministry of Health de-veloped a case ... cases of pandemic (H1N1) 2009 influenza is markedly different from the disease pattern seen during epidemics of seasonal influenza, in that many of those affected were previ-ously healthy young ... microbiologic findings, and chest radi-ologic findings at ICU admission. Intubation and mechanical ventilation requirements, adverse events during ICU stay and laboratory findings at ICU ad-mission...
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Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
... subfamily of the cytoch-rome P450 (CYP) enzymatic system, is responsible for the metabolism of tacrolimus [10]. Specifically; tacro-limus is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. ... The alleles A and G are CYP3A5*1 and CYP3A5*3, respectively. Indi-viduals carrying at least one CYP3A5*1 allele express CYP3A5 protein whereas individuals homozygotes for CYP3A5*3 are non-expressors ... USA 3. Department of Medical Physics, School of Medicine, University of Patras, Rion, Greece 4. Department of Internal Medicine-Nephrology, School of Medicine, University of Patras, Rion, Greece...
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Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatmen"
... limit of detection of 28 IU/mL. Body weight measurement and laboratory data were collected and compared at the beginning and at the end of therapy. The Knodell scoring sys-tem for liver biopsy ... combined pegylated interferon alfa-2a or alfa-2b plus ribavirin. Genotypes of HCV were defined using the Bayer TRUGENE HCV Genotyping Test. Serum concentra-tion of HCV RNA was determined ... and cytokines but findings are not con-sistent (21-24). Alternatively, several studies showed that TNF levels were not increased during interferon therapy and postulated other mechanisms of...
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Báo cáo y học: "Postoperative pain scores and analgesic requirements after thyroid surgery: Comparison of three intraoperative opioid regimens"
... administered in all patients. Pain scores, opioid demand and the length of stay in PACU were assessed in a blind manner. Results: Post operative pain scores were significantly lower in the fentanyl and ... 12vomiting and sedation score (0=awake, 1=mild, 2=sleepy but awakable, and 3 = very sleepy) and the length of stay in the PACU. The latter was decided by a physician unaware of the randomisation ... only in 1/3 of patients after sufentanil and fentanyl based analgesia while almost always necessary in case of remifentanil based analgesia. The necessity of anticipation of postoperative pain...
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Báo cáo y học: "yrosine kinase – Role and significance in Cancer"
... transforming non receptor tyrosine kinase activity [4], and the finding of EGFR, the first receptor tyrosine kinase paved the way to the understanding of the role and significance of tyrosine kinase ... mechanism of action of tyrosine kinase Tyrosine kinases are enzymes that selectively phosphorylates tyrosine residue in different substrates. Receptor tyrosine kinases are activated by ligand binding ... proteins containing Src homology-2 (SH2) and protein tyrosine binding (PTB) domains. These proteins in turn recruit additional effector molecules having SH2, SH3, PTB and Pleckstrin homology (PH)...
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