... activation (Eur. J. Biochem. 269) 6151 Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein–protein interactions Hongmei Yang1, Charles H. Lin2, Gang Ma1, ... intrinsic transcriptional activity. Fig. 2. The transcriptional activity of IRF-3 depends on synergy betweentwo sets of residues and is entirely dependent on mammalian CBP. (A) Transcriptional activity ... Virus-specificactivation of a novel interferon regulatory factor, IRF-5, results inthe induction of distinct interferon alpha genes. J. Biol. Chem. 276,23382–23390.18. Suhara, W., Yoneyama, M., Iwamura, T., Yoshimura,...