Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf
Báo cáo Y học: Incorporation of 3-nitrotyrosine into the C-terminus of a-tubulin is reversible and not detrimental to dividing cells potx
... frompeptides and proteins. The other, tubulin carboxypeptidase,participates in the physiological tyrosination/detyrosinationcycle producing selective release of C-terminal tyrosine from the a-tubulin ... nitrotyrosinated tubulin isindistinguishable from normal tubulin in the assemblyprocess. Judging by these results, substitution of tyrosine byits analogue 3-nitrotyrosine at the C-terminus of ... fully nitrotyrosinated, whereas in the absence of nitrotyrosine (from day 4–6) tubulin lost allits C-terminal nitrotyrosine. The six cell lines remainedviable and divided normally during the cycle...
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Báo cáo y học: "Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections"
... primary and hospital care. The ultimate clinicalutility of a biomarker is defined by the degree it improvesclinical decision making and adds timely informationbeyond that of readily available information ... infection isa dynamic continuum and in the majority a sequelae of CAP [54]. The severity of a disease determines the con-sumption of costly and limited health-care resources. Anearly and adequate ... mortalityrisks and rely mostly on age as the main driver of mortal-ity [4]. However, calculation of the PSI in daily practice istime consuming which limits its dissemination and implementation in...
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Báo cáo y học: " Evaluation of Lumbar Facet Joint Nerve Blocks in Managing Chronic Low Back Pain: A Randomized, Double-Blind, Controlled Trial with a 2-Year Follow-U"
... Efficacy and validity of radiofrequency neurotomy for chronic lumbar zygapophysial joint pain. Spine (Phila Pa 1976). 2000; 25: 1270-7. 32. Merskey H, Bogduk N. Lumbar zygapophysial joint pain. In: ... Classification of Chronic Pain; Descriptions of Chronic Pain Syndromes and Definition of Pain Terms, 2nd ed; Task Force on Taxonomy of the International Association for the Study of Pain. Seattle: ... to change the outcomes. The number of joints involved was as follows: 2 joints were involved in 70% of the patients and 3 joints were involved in 30% of the patients. Bilateral in- volvement...
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Báo cáo y học: "Effect of 1,25-dihydroxy-vitamin D3 in experimental sepss"
... inflammatory cytokines, TNF-alpha and cer-tain interleukins play a key-role in initiating systemic inflammatory response syndrome (SIRS) and it is known that vitamin D may modulate the cytokine ex-pression ... and, therefore, by both autocrine and paracrin stimulation influence their own macrophage activity in addition to the T- and B-lymphocyte dif-ferentiation and activity [11,12,13]. The inflammatory ... monocytes and macro-phages by interacting with specific vitamin D receptors in the myeloid tissue cells [9,10]. The macrophages themselves produce and excrete this active form of vitamin D and, ...
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Báo cáo y học: "Efficiency of vibration exercise for glycemic control in type 2 diabetes patients."
... Moreover, in the control group (flexibility training) and the strength training group HbA1c increased by 5 % and 3 %, respectively. This finding is clearly inconsistent with the outcome of other ... strength training and a control group (flexibility training) on glycemic control in type 2 diabetes patients. Forty adult non-insulin dependent patients participated in the intervention. Fasting glucose ... Köln, Germany and Trainingsinstitut Prof. Dr. Baum GmbH, Köln, Germany 2. Trainingsinstitut Prof. Dr. Baum GmbH, Köln, Germany Correspondence to: Klaus Baum, Prof. Dr., Trainingsinstitut, Wilhelm-Schlombs-Allee...
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Báo cáo y học: "Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout Lisa Cammalleri and Mariano Malaguarnera"
... guanosine monophosphate (GMP), the purinic nucleotides useful for DNA and RNA synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid. Hypoxanthine ... urate (tophi) in soft tissues around joints, in kidney and in subcutaneous tissue. Kidney is one of the most involved organs in case of hyperuricemia, because it is the main site of uric acid ... orally both in TLS and in gout. A large body of evidence confirms the efficacy and safety of rasburicase, even in comparison to the standard drugs used in the aforementioned pathologies. Key words:...
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Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
... ±Birkprotease inhibitors [5], metallothioneins [6], prothymosina [7], a bacterial ®bronectin-binding protein [8], the brainprotein a-synuclein together with the related proteinsb-synuclein and c-synuclein ... relies mainly on the evidence outlined above. In view of the c lose similarity of the ROA spectra of the casein, synuclein and tau proteins shown in t his paper, wehave reproduced in F ig. 1 ... scanning cal-orimetry, of bovine b-andj-casein, recombinant human a-,b-andc-synuclein, together with the A30P and A53T mu-tants of a-synuclein associated with familial cases of Par-kinson's...
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Báo cáo Y học: Role of three isoforms of phospholipase A2 in capacitative calcium influx in human T-cells pot
... T-cellsconstitutively express the mRNA of four PLA2isotypes(type IB, type V, type IV and type VI). Interestingly,addition of TG stimulated the induction of the four PLA2isotypes in Jurkat T-cells.PLA2inhibitors ... acid and BPB, the inhibitors of type IB and type V, and BEL, an inhibitor of type VI,inhibited significantly the TG-induced [3H]AA release. The type IV-PLA2does not seem to play a role in the ... calcium in ux, AA and then CaCl2were sequentially added or not into the cuvette without interruptions in the recordings. The control trace shows the recording observed in the absence of AA and...
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Báo cáo Y học: Defective translocation of a signal sequence mutant in a prlA4 suppressor strain of Escherichia coli doc
... directly after the pulse in the wild-type strain. In the prlA7 and prlA202suppressor strains, processing was improved and the amount of mature PhoE increased to 50% and 60%,respectively, of the ... translocation. The prlA4phenotype of the strain was confirmed by studying the processing kinetics of (G-10R)prePhoE. The translocation of this mutant precursor, which contains a charged residue in the hydrophobic ... that the prlA4 mutation in secYreduced the pmf dependency of protein translocation [21].Similarly, a single amino- acid substitution, replacing the helix-breaking glycine at position )10 in the...
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Báo cáo Y học: Two independent, light-sensing two-component systems in a filamentous cyanobacterium pot
... to the kinase motifs in the C-terminal domain and to large portions of the proteins in the N-terminal part that include the chromophore-binding domain [8–11,13,14,16,21]. The interesting case in ... transduction in Synechocystis sp. once the photoreceptor is activated by absorption of a photon. While the N-terminal part of the phytochrome-like protein of Synechocystis sp. incorporates the chromophore, ... in Synechocystis sp. has revealed further members of this protein family in a number of other cyanobacteria and eubacteria [14,21]. Some of these proteins even lack the covalent-binding forming...
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