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Báo cáo khoa học: "ON THE INTONATION OF MONO- AND DI-SYLLABIC WORDS WITHIN THE DISCOURSE FRAMEWORK OF CONVERSATIONAL GAMES ON THE INTONATION OF MONO- AND DI-SYLLABIC WORDS WITHIN THE DISCOURSE FRAMEWORK OF CONVERSATIONAL GAMES " pot

Báo cáo khoa học: Molecular basis for substrate recognition and drug ˚ resistance from 1.1 to 1.6 A resolution crystal structures of HIV-1 protease mutants with substrate analogs pptx

Báo cáo khoa học: Molecular basis for substrate recognition and drug ˚ resistance from 1.1 to 1.6 A resolution crystal structures of HIV-1 protease mutants with substrate analogs pptx

... adoptedtwo conformations, which differed by a rotation of  90°. One conformation of P2 Asn maintained weakerhydrogen bonds with Asp29 and 30, while the otherconformation was surrounded by the hydrophobic ... respectively. The PR concentrations were determined by active site titrationswith indinavir, and the substrate concentration was deter-mined by converting the absorbance of the substrate toconcentration ... liesbetween the flap region (Ile50 and 50¢) and P2 and P1¢ of the inhibitor, which has been proven to be import-ant for catalysis [30,31], and the other mediates the interactions of P2¢ with Gly27¢ and...
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Tài liệu Báo cáo khóa học: Determination by electrospray mass spectrometry and 1H-NMR spectroscopy of primary structures of variously fucosylated neutral oligosaccharides based on the iso-lacto-N-octaose core doc

Tài liệu Báo cáo khóa học: Determination by electrospray mass spectrometry and 1H-NMR spectroscopy of primary structures of variously fucosylated neutral oligosaccharides based on the iso-lacto-N-octaose core doc

... 6-branch, and believed to befrom a contaminant (see below), having the same molecularmass with one Fuc in each of the 3- and 6-branches.Comparison of the product-ion spectra of the singly and doubly ... by cone voltage fragmentation [14]. The fragment ions of m/z 729 and m/z 544 are both from the monofucosylated D2b-5ion m/z 1037 and not from the difucosylated D2b-5ion m/z 1183.Thus the ... particularly in the postgenome era, in order to understand post-translationalglycosylation and its function. Expansion of our knowledge on the repertoire of carbohydrate structures, the ÔglycomeÕ, and investigation...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... transcription of the ITK gene and is key for the productive infection of HIV in these cells. Accord-ingly, the inhibition of ITK activity compromises HIVinfection, gene expression and replication [62].Our ... 2001–2010 ª 2011 The Authors Journal compilation ª 2011 FEBSMINIREVIEWTEC family kinases in health and disease – loss -of- function of BTK and ITK and the gain -of- function fusions ITK–SYK and BTK–SYKAlamdar ... differences between B and T lymphocyteswith regard to their response to different TFK fusions, and also raises the important question of the outcome of the corresponding translocation involving BTK...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf

Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf

... preventdegradation. A common drawback of such approachesis the cost of the affinity resins used to isolate the fusion protein and the proteases required to liberate the protein of interest from the fusion ... than gel filtration due to morerapid handling using the devices and loss of peptide on the column resin. The only detriment of the peptidesproduced here is the fact that they contain an exo-genous ... E22K, E22Q and D23N), and the availability of a rapid and simpleexpression and purification protocol will facilitatelarge-scale investigations of the molecular determinants of aggregation and fibrillation....
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Tài liệu Báo cáo khoa học: Long-distance interactions between enhancers and promoters The case of the Abd-B domain of the Drosophila bithorax complex pdf

Tài liệu Báo cáo khoa học: Long-distance interactions between enhancers and promoters The case of the Abd-B domain of the Drosophila bithorax complex pdf

... todesignate the phenomenon when the expression of agene on one chromosome depends on the pairingwith its homologous region [14]) The degree of com-plementation in A7 depends on the size of the pro-moter ... (indica-ted by the thickness of the curved arrows) of the cis and transinteractions in favor of the latter. An increase in the trans inter-action results in an increase in the level of the functional ... However, when the combination of the PTS and the bound-ary is placed 3¢ to one of the reporter genes, the enhancer istargeted to one or the other promoter over the boundary (lowerpanel). E1 and E2:...
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Báo cáo khoa học: Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with D-galactose-induced aging pdf

Báo cáo khoa học: Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with D-galactose-induced aging pdf

... detect the presence of the common deletion in the inner ear in the control group. The proportions of the common deletion in the inner ear in the low-dose,medium-dose and high-dose groups of d-Gal-treatedrats ... calculate the abundance of the mitochondrial common deletion, and the proportion of deletion was calculated with the equationR =2)DCT· 100%.Mitochondrial DNA copy number assay The mtDNA copy ... amplify the process of the clonal expansion of mtDNA mutations, withpotentially detrimental long-term consequences [38].However, in postmitotic cells such as neurons, there isno cell division, and...
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Báo cáo khoa học: Purification, characterization, cDNA cloning and nucleotide sequencing of a cellulase from the yellow-spotted longicorn beetle, Psacothea hilaris ppt

Báo cáo khoa học: Purification, characterization, cDNA cloning and nucleotide sequencing of a cellulase from the yellow-spotted longicorn beetle, Psacothea hilaris ppt

... purifiedfrom the gut of larvae of the yellow-spotted longicorn beetlePsacothea hilaris by acetone precipitation and elution fromgels after native PAGE and SDS/PAGE with activitystaining. The purified ... reported that the addition of acetoneto the reaction buffer increased transglycosylation activity of the Rhodotorula glutinis cellulase. Observation of trans-glycosylation activity in the purified ... After elution and concentration of the protein solution containing the cellulase activity after nativePAGE, the solution was mixed with sample buffer for SDS/PAGE without reducing agent and incubated...
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Báo cáo khoa học:

Báo cáo khoa học: "PCFGs, Topic Models, Adaptor Grammars and Learning Topical Collocations and the Structure of Proper Names" ppt

... sequences of words rather than sin-gle words. Then we adapt each of the Topicinon-terminals, which means that we learn the probabil-ity of each of the sequences of words it can expandto.Sentence ... and Docnonterminals — but ithas the advantage that the LDA distributions mapstraight-forwardly onto PCFG nonterminals). The terminals W of the CFG consist of the vo-cabulary V of the LDA model ... collocations generated by anAG. The second extension builds on the first one to learn aspects of the internalstructure of proper names.1 IntroductionOver the last few years there has been consider-able...
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Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx

Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx

... selection [5–7]. Furthermore, combined deletion of Itk and Rlk leads to a further reduction in the TCRsignal strength, resulting in the conversion of negativeto positive selection and a rescue of ... cells and has been shown to be critical for the development, function and differentiation of conventional ab T cells.However, less is known about its role in nonconventional T cells such asNKT and ... ornonconventional T cells, may develop via an indepen-dent pathway, dependent on expression of major histo-compatability complex molecules on bone-marrow-derived cells. These nonconventional...
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Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

... they arehydrophobic and negatively charged. A comparison of rhodamine uptake, in the presence and the absence of uncouplers, allows the estimation of the effect of intracellular binding on the ... altered by NBD-Cl. On the other hand,NBD-Cl enhanced the fluorescence of TMRM takenup into nonrespiring cells, but had little effect on the distribution of the dye within the cells.NBD-Cl is ... whose mitochondria had beenpoisoned to rhodamines, quasi-equilibrium is achieved within 1 h. Contrary to our expectations, under theseconditions, the free concentration of the dyes in the cytoplasm...
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