... metabolism. The functional association wasfurther aided by integration of protein interactiondata with data on gene expression, localization, func-tion, evolutionary conservation, protein structure andbinary ... signal-transductionpathways. One of the key considerations in suchscreens is the choice of appropriate read-out assaysthat can accurately assess the effect of gene knock-down on the pathway of interest ... V,Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C,Greenblatt JF, et al. (2005) Exploration of the functionand organization of the yeast early secretory pathwaythrough an epistatic miniarray...